Clinical research
GABA-A receptor genes do not play a role in genetics of Lesch’s typology in Caucasian subjects
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Submission date: 2011-02-04
Final revision date: 2011-07-15
Acceptance date: 2011-07-24
Online publication date: 2012-05-09
Publication date: 2012-04-30
Arch Med Sci 2012;8(2):357–361
Introduction: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system.
Material and methods: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch’s typology and in 145 matched controls.
Results: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls.
Conclusions: Lesch’s typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.