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NUTRITION / CLINICAL RESEARCH
Association of micronuclei frequency and other nuclear anomalies with flaxseed diet in metabolic syndrome patients
1
Departamento de Disciplinas Filosófico, Metodológico e Instrumentales; Departamento de Morfología. Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG); División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO)-IMSS. Guadalajara, Jalisco, México
2
Departamento de Enfermería Clínica Aplicada (DECA), CUCS, UdG, Guadalajara, Jalisco, México
3
Departamento de Salud Pública, CUCS, UdG. Guadalajara, Jalisco, México; Unidad de Medicina Familiar No. 51, Delegación Jalisco, Instituto Mexicano del Seguro Social, Zapopan, Jalisco, México
4
Servicio de Nutrición Clínica, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México
5
Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, UdG. Guadalajara, Jalisco, México
6
Servicio de Neonatología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México
7
Universidad del Valle de México, Zapopan, Jalisco, México
8
Coordinación de Planeación, CUCS, UdG. Guadalajara, Jalisco, México
9
Departamento de Ingeniería Química y Bioquímica, Instituto Tecnológico de Jiquilpan. Jiquilpan, Michoacán, México
Submission date: 2020-01-13
Final revision date: 2020-05-27
Acceptance date: 2020-06-04
Online publication date: 2020-07-13
Publication date: 2026-04-30
Corresponding author
Ana Lilia Fletes-Rayas
Departamento de Enfermería, Clínica Aplicada (DECA) CUCS, UdG, Guadalajara Jalisco, México
Departamento de Enfermería, Clínica Aplicada (DECA) CUCS, UdG, Guadalajara Jalisco, México
Arch Med Sci 2026;22(2):663-671
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This study aimed to investigate whether a rich flaxseed diet could modify the micronuclei frequency, nuclear anomalies and biochemical and anthropometric parameters in metabolic syndrome patients.
Material and methods:
Fifty-eight patients with metabolic syndrome were dichotomized into two groups, namely, the control group (CG) and the intervention group (IG), and the patients in the IG received a diet supplemented with flaxseed. The anthropometric and clinical parameters were measured. Nuclear anomalies isolated from the oral mucosa were analyzed at the beginning and end of the 3-month follow-up.
Results:
After the nutritional follow-up, the percentage of fat was decreased in the CG (before, 45.40%; after, 37.89%, p < 0.001). In the IG, the weight (before, 81.03 ±13.17 kg; after, 79.81 ±13.47 kg, p = 0.01), body mass index (before, 32.7 ±5.4; after, 32.2 ±5.6, p = 0.009) and very-low-density lipoprotein (before, 31.96 ±15.23; after, 26.13 ±7.54, p = 0.04) were decreased. The frequencies of MN (micronucleated) and BN (binucleated) cells were decreased in the CG (before, 14.03 ±5.28, after 11.17 ±3.68; before, 2.66 ±3.5, after, 1.10 ±1.66; p = 0.001/0.02, respectively), while in the IG, the frequencies of MN and BN cells and NB (nuclear buds) were decreased (MN before, 4.97 ±5.47, after, 1.38 ±1.97 [p = 0.02]; BN before, 23.69 ±21.93, after, 10.66 ±10.34 [p = 0.007]; and NB before, 5.10 ±6.63, after, 2.17 ±2.74 [p = 0.03]).
Conclusions:
The group that consumed a diet supplemented with flaxseed showed greater decreases in weight, body mass index and very-low-density lipoprotein than the CG. The numbers of nuclear anomalies were decreased in both groups, but greater mean decreases in micronuclei and binuclear cells were observed in the IG after 3 months.
This study aimed to investigate whether a rich flaxseed diet could modify the micronuclei frequency, nuclear anomalies and biochemical and anthropometric parameters in metabolic syndrome patients.
Material and methods:
Fifty-eight patients with metabolic syndrome were dichotomized into two groups, namely, the control group (CG) and the intervention group (IG), and the patients in the IG received a diet supplemented with flaxseed. The anthropometric and clinical parameters were measured. Nuclear anomalies isolated from the oral mucosa were analyzed at the beginning and end of the 3-month follow-up.
Results:
After the nutritional follow-up, the percentage of fat was decreased in the CG (before, 45.40%; after, 37.89%, p < 0.001). In the IG, the weight (before, 81.03 ±13.17 kg; after, 79.81 ±13.47 kg, p = 0.01), body mass index (before, 32.7 ±5.4; after, 32.2 ±5.6, p = 0.009) and very-low-density lipoprotein (before, 31.96 ±15.23; after, 26.13 ±7.54, p = 0.04) were decreased. The frequencies of MN (micronucleated) and BN (binucleated) cells were decreased in the CG (before, 14.03 ±5.28, after 11.17 ±3.68; before, 2.66 ±3.5, after, 1.10 ±1.66; p = 0.001/0.02, respectively), while in the IG, the frequencies of MN and BN cells and NB (nuclear buds) were decreased (MN before, 4.97 ±5.47, after, 1.38 ±1.97 [p = 0.02]; BN before, 23.69 ±21.93, after, 10.66 ±10.34 [p = 0.007]; and NB before, 5.10 ±6.63, after, 2.17 ±2.74 [p = 0.03]).
Conclusions:
The group that consumed a diet supplemented with flaxseed showed greater decreases in weight, body mass index and very-low-density lipoprotein than the CG. The numbers of nuclear anomalies were decreased in both groups, but greater mean decreases in micronuclei and binuclear cells were observed in the IG after 3 months.
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