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VASCULAR IMAGING / CLINICAL RESEARCH
Effectiveness of low-tube current for reducing radiation dose in cerebral CT perfusion
1
Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin, China
Submission date: 2019-10-16
Final revision date: 2020-04-13
Acceptance date: 2020-05-09
Online publication date: 2021-04-13
Publication date: 2026-02-28
Corresponding author
Song Jin
Department of Radiology Tianjin Huanhu Hospital Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases No. 6 Jizhao Road Jinnan District, Tianjin 300350, China Phone/fax: +86 020 5906 5662
Department of Radiology Tianjin Huanhu Hospital Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases No. 6 Jizhao Road Jinnan District, Tianjin 300350, China Phone/fax: +86 020 5906 5662
Arch Med Sci 2026;22(1):104-113
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This study aims to investigate the reduction of radiation dose in cerebral computed tomography (CT) perfusion by lower low-tube current.
Material and methods:
Two hundred patients, who underwent cerebral non-contrast CT and CT perfusion, were randomized to four groups according to tube current and contrast media (CM) concentration: group A (60 mAs, 320 mg I/ml), group B (60 mAs, 370 mg I/ml), group C (100 mAs, 320 mg I/ml), and group D (100 mAs, 370 mg I/ml). Among these four groups, the CT dose index (CTDIvol), dose length product (DLP) and effective dose (ED) were calculated. The quantitative image comparison included maximum enhancement, noise, signal-to-noise ratio (SNR), cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) from five regions of interests (ROIs).
Results:
Ranging from 100 mAs to 60 mAs, groups A and B achieved 40% lower CTDIvol, DLP and ED, compared with groups C and D. Both the maximum enhancement and noise of all ROIs were higher in groups A and B than in groups C and D (p < 0.05). The CBV values were higher in groups B and D than in groups A and C (p < 0.05). The image quality (IQ) of each group of perfusion maps met the requirements for imaging diagnosis.
Conclusions:
The reduction in tube current from 100 mAs to 60 mAs for cerebral CT perfusion led to a 40% reduction in radiation dose without sacrificing image quality.
This study aims to investigate the reduction of radiation dose in cerebral computed tomography (CT) perfusion by lower low-tube current.
Material and methods:
Two hundred patients, who underwent cerebral non-contrast CT and CT perfusion, were randomized to four groups according to tube current and contrast media (CM) concentration: group A (60 mAs, 320 mg I/ml), group B (60 mAs, 370 mg I/ml), group C (100 mAs, 320 mg I/ml), and group D (100 mAs, 370 mg I/ml). Among these four groups, the CT dose index (CTDIvol), dose length product (DLP) and effective dose (ED) were calculated. The quantitative image comparison included maximum enhancement, noise, signal-to-noise ratio (SNR), cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) from five regions of interests (ROIs).
Results:
Ranging from 100 mAs to 60 mAs, groups A and B achieved 40% lower CTDIvol, DLP and ED, compared with groups C and D. Both the maximum enhancement and noise of all ROIs were higher in groups A and B than in groups C and D (p < 0.05). The CBV values were higher in groups B and D than in groups A and C (p < 0.05). The image quality (IQ) of each group of perfusion maps met the requirements for imaging diagnosis.
Conclusions:
The reduction in tube current from 100 mAs to 60 mAs for cerebral CT perfusion led to a 40% reduction in radiation dose without sacrificing image quality.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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