RHEUMATOLOGY / RESEARCH PAPER
Interplay between IL-17 family members and angiogenic cytokines in subjects with systemic sclerosis.
 
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1
Department of Dermatology and Venereology, Medical University of Lodz 90-647 Lodz, Plac J. Hallera 1/6, Poland, Poland
2
University of Economics and Human Sciences in Warsaw, ul. Okopowa 59, 01-043 Warsaw, Poland
3
Department of Dermatology and Venereology, Medical University of Lodz, Plac J. Hallera 1/6, 90-647 Lodz, Poland
4
Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, Poland, Poland
CORRESPONDING AUTHOR
Ewa Robak   

Department of Dermatology and Venereology, Medical University of Lodz 90-647 Lodz, Plac J. Hallera 1/6, Poland, Poland
Submission date: 2020-02-09
Final revision date: 2020-09-16
Acceptance date: 2020-10-03
Online publication date: 2021-03-21
 
 
KEYWORDS
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ABSTRACT
Introduction:
Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease characterized by immune system activation, vasculopathy, and collagen accumulation. Despite progressive fibrosis of the vasculature, compensatory angiogenesis is impaired. The cause of the shift towards anti-angiogenesis observed in SSc is unknown. The IL-17 cytokine family participates in the pathogenesis of SSc and angiogenesis.

Material and methods:
Our study aimed to evaluate levels and find relationships between the levels of proangiogenic cytokines and cytokines from the IL-17 family in 42 SSc subjects and 20 healthy controls. VEGF, PlGF, HGF, TGFβ1, GM-CSF, IL-17A, IL-17B, IL-17E and IL-17F were quantified in the sera of all participants by ELISA sandwich kits.

Results:
Significantly higher mean concentrations of PlGF compared to controls - mean value (19.3 pg/ml in the SSc group vs. 11.4 pg/ml in the control group; p<0.001) and of HGF (1931 pg/ml in the SSc group vs. 1483 pg/ml in controls; p<0.05). Mean serum TGFβ1 level was also significantly lower in the SSc group (781 pg/ml) than controls (35991 pg/ml; p<0.001). Among the IL-17 family, significantly higher mean concentrations of IL-17B (67.0 pg/ml vs. 2.6 pg/ml in controls; p<0,001), IL-17E (8.0 pg/ml vs 0.64 pg/ml in controls; p<0.001) and IL-17F (0.42 pg/ml vs. 0.0 pg/ml in controls; p< 0.01) were detected. Serum concentrations of HGF and PlGF correlated with the concentrations of IL17A, IL-17B, and IL-17E.

Conclusions:
In conclusion, our findings indicate that selected cytokines from the IL17 family participate in the pathogenesis of SSc and are responsible for the vascular abnormalities associated with this disorder.

eISSN:1896-9151
ISSN:1734-1922