Letter to the Editor
Catastrophic antiphospholipid syndrome in a patient with V Leiden variant
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Submission date: 2011-03-04
Final revision date: 2011-06-25
Acceptance date: 2011-07-31
Online publication date: 2012-12-19
Publication date: 2012-12-31
Arch Med Sci 2012;8(6):1117-1119
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by a thrombophilic state with pregnancy complications and the presence of circulating antiphospholipid (aPL) antibodies. This syndrome rarely may present with rapidly recurring thrombotic events involving predominantly small vessels of many organs; this presentation is defined as catastrophic APS or Asherson’s syndrome. We report a case of a woman with multi-systemic dysfunction consisting of cerebral symptoms, cardio-pulmonary disease, and renal insufficiency who tested positive for aPL antibodies and factor V Leiden variant.
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