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NEONATOLOGY / RESEARCH PAPER
Therapeutic effect of Lactobacillus reuteri DSM 17938 on feeding intolerance in preterm infants
1
Department of Pediatrics, Beijing United Family Hospital, Beijing, China
Submission date: 2022-10-09
Final revision date: 2023-01-13
Acceptance date: 2023-01-27
Online publication date: 2023-02-04
Corresponding author
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Preterm infants have an immature gastrointestinal tract with incomplete establishment of intestinal flora; therefore, they are highly prone to feeding intolerance. The objective of the study was to observe the therapeutic effect of specific probiotics (Lactobacillus reuteri DSM 17938) on feeding intolerance in preterm infants.
Material and methods:
Fifty-six preterm infants delivered between January 2016 and May 2022 were enrolled in this retrospective study. We analysed the clinical data of these children and followed up their treatment outcomes by telephone for 3 to 6 months after discharge. The treatment schemes were scheme A (n = 28), which included adjusted feeding (micro-feeding and intermittent feeding) and oral exercise intervention, and scheme B (n = 28), in which specific probiotics (L. reuteri DSM 17938) were given on the basis of scheme A.
Results:
Among the 56 children were 31 males and 25 females. In scheme B, the duration of switching from intravenous nutrition to full enteral feeding at a gestational age of > 28 weeks and a birth weight of ≤ 1,500 g was significantly different from that in scheme A (p < 0.05). The duration of vomiting at a gestational age of > 28 weeks was also significantly different from that of scheme A. There were statistically significant differences in the treatment effect of feeding intolerance in the preterm infants.
Conclusions:
Lactobacillus reuteri DSM 17938 combined with the routine treatment of premature infants with feeding intolerance has a better effect. Returning to normal feeding as soon as possible can reduce the incidence of gastrointestinal complications and promote growth in preterm infants.
Preterm infants have an immature gastrointestinal tract with incomplete establishment of intestinal flora; therefore, they are highly prone to feeding intolerance. The objective of the study was to observe the therapeutic effect of specific probiotics (Lactobacillus reuteri DSM 17938) on feeding intolerance in preterm infants.
Material and methods:
Fifty-six preterm infants delivered between January 2016 and May 2022 were enrolled in this retrospective study. We analysed the clinical data of these children and followed up their treatment outcomes by telephone for 3 to 6 months after discharge. The treatment schemes were scheme A (n = 28), which included adjusted feeding (micro-feeding and intermittent feeding) and oral exercise intervention, and scheme B (n = 28), in which specific probiotics (L. reuteri DSM 17938) were given on the basis of scheme A.
Results:
Among the 56 children were 31 males and 25 females. In scheme B, the duration of switching from intravenous nutrition to full enteral feeding at a gestational age of > 28 weeks and a birth weight of ≤ 1,500 g was significantly different from that in scheme A (p < 0.05). The duration of vomiting at a gestational age of > 28 weeks was also significantly different from that of scheme A. There were statistically significant differences in the treatment effect of feeding intolerance in the preterm infants.
Conclusions:
Lactobacillus reuteri DSM 17938 combined with the routine treatment of premature infants with feeding intolerance has a better effect. Returning to normal feeding as soon as possible can reduce the incidence of gastrointestinal complications and promote growth in preterm infants.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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