Basic research
Association study of COX-2 (PTGS2) –765 G/C promoter polymorphism by pyrosequencing in Sicilian patients with Alzheimer’s disease
Association study of COX-2 (PTGS2) –765 G/C promoter polymorphism by pyrosequencing in Sicilian patients with Alzheimer’s disease
Submission date: 2013-02-18
Final revision date: 2013-06-10
Acceptance date: 2013-06-18
Online publication date: 2014-12-22
Publication date: 2014-12-17
Arch Med Sci 2014;10(6):1235–1238
KEYWORDS
TOPICS
ABSTRACT
Introduction: Alzheimer’s disease (AD) is characterized by progression of memory problems to a slow global decline of cognitive function. Inflammation when left unregulated becomes a major cofactor in the pathogenesis of AD. PTGS2 is of crucial relevance in the inflammatory response, and it has been shown to play a considerable role in AD pathogenesis.
Material and methods: To assess the possible putative role of a PTGS2 polymorphism (–765 G/C) in AD patients, we examined, by pyrosequencing, its distribution in 84 Sicilian AD patients and in 80 controls.
Results: No significant statistical difference in PTGS2 –765 G/C genotype distribution was found comparing patients with AD and controls. In addition, no significant difference was observed in the distribution of the PTGS2 –765 alleles between AD patients and controls.
Conclusions: These findings suggest that the PTGS2 –765 G/C polymorphism may not be associated with AD in the Sicilian population.
Material and methods: To assess the possible putative role of a PTGS2 polymorphism (–765 G/C) in AD patients, we examined, by pyrosequencing, its distribution in 84 Sicilian AD patients and in 80 controls.
Results: No significant statistical difference in PTGS2 –765 G/C genotype distribution was found comparing patients with AD and controls. In addition, no significant difference was observed in the distribution of the PTGS2 –765 alleles between AD patients and controls.
Conclusions: These findings suggest that the PTGS2 –765 G/C polymorphism may not be associated with AD in the Sicilian population.
Share
RELATED ARTICLE
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.