Clinical research
A pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillation
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Submission date: 2011-04-12
Final revision date: 2011-10-08
Acceptance date: 2011-11-03
Online publication date: 2012-06-26
Publication date: 2012-06-30
Arch Med Sci 2012;8(3):471–476
Introduction: The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor- γ (PPAR-γ) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).
Material and methods: We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-γ receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-a (TNF-α). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.
Results: The concentration of PPAR- γ receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-α were higher than those in the control group (all p < 0.01). The PPAR-γ level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-γ, hs-CRP, TNF-α and LAD level were associated with AF.
Conclusions: Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-γ receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-γ may take part in the pathogenesis of AF.