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ONCOLOGY / RESEARCH LETTER
Gedunin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine
1
Department of General Surgery, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China
These authors had equal contribution to this work
Submission date: 2023-12-17
Final revision date: 2024-01-27
Acceptance date: 2024-02-03
Online publication date: 2024-03-30
Arch Med Sci 2024;20(2):691-697
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.
Material and methods:
Fifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1–4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.
Results:
Gedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.
Conclusions:
Gedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.
This study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.
Material and methods:
Fifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1–4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.
Results:
Gedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.
Conclusions:
Gedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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