ONCOLOGY / RESEARCH PAPER
 
KEYWORDS
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ABSTRACT
Introduction:
One of the simplest nanostructures that is widely used in industry today is metallic nanoparticles. Metallic ‎nanoparticles can bind non-destructively to single-stranded DNA, which are important in medical diagnostics. ‎Cancer nanotechnology developed a new area of integrative research in biology, chemistry, engineering, and ‎medicine, and is concerned with major advances in cancer diagnosis, prevention and treatment ‎

Material and methods:
‎ In the recent study, the structural and morphological characterization of bio‐synthesized FeNPs@Calendula ‎arvensis was performed by FT-IR and UV-vis spectroscopy, scanning electron microscopy (SEM) that SEM ‎images have exhibited an equal and uniform spherical morphology in size of 30.13 nm. ‎

Results:
In the antioxidant test, the IC50 of FeNPs@Calendula arvensis and BHT against DPPH free radicals were 117 ‎and 88 µg/mL, respectively. In the anticancer test, the treated cells with FeNPs@Calendula arvensis were ‎assessed by MTT assay for 48h about the anti-human cholangiocarcinoma and ‎ cytotoxicity properties on normal ‎‎(HUVEC) and cholangiocarcinoma ‎ carcinoma cell lines i.e., HCM-CSHL-0174-C22, CCLP-1, and QBC939. ‎The IC50 of FeNPs@Calendula arvensis were 196, 237, and 278 µg/mL against HCM-CSHL-0174-C22, ‎CCLP-1, and QBC939‎ cell lines, respectively. The viability of cholangiocarcinoma cell line reduced dose-‎dependently in the presence of FeNPs@Calendula arvensis.‎

Conclusions:
It appears that the anti-human cholangiocarcinoma effect of FeNPs@Calendula arvensis is due to their ‎antioxidant effects.‎

eISSN:1896-9151
ISSN:1734-1922