Magnetic resonance white matter changes
in patients with obstructive sleep apnoea.
The subset of the PURE-MIND (Prospective Urban
and Rural Epidemiological) cohort study
| 1 | Department of Internal Medicine, 4th Military Hospital, Wroclaw, Poland |
| 2 | Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University,
Wroclaw, Poland |
| 3 | Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical
University, Wroclaw, Poland |
| 4 | Department of Social Medicine, Wroclaw Medical University, Wroclaw, Poland |
| 5 | Department of Mathematics, Faculty of Environmental Engineering and Geodesy,
Wrocław University of Environmental and Life Sciences, Wroclaw, Poland |
| 6 | University of Saskatchewan, Saskatoon, Canada |
CORRESPONDING AUTHOR
Submission date: 2020-03-04
Final revision date: 2020-07-14
Acceptance date: 2020-07-14
Online publication date: 2021-03-10
KEYWORDS
obstructive sleep apnoeacerebral small vessel diseasemagnetic resonance imagingwhite matter hyperintensities
TOPICS
ABSTRACT
Introduction:
Changes typical for cerebral small vessel disease (i.a. white matter hyperintensities – WMHs) are often found accidentally in neuroimaging studies. Although asymptomatic, this condition increases the risk of future ischaemic incidents and neurodegenerative disorders. Sleep apnoea is a recognised risk factor for vascular diseases. The aim of our study was to assess the prevalence of, and association between, obstructive sleep apnea (OSA) and cerebral small vessel disease in the studied population.
Material and methods:
Two hundred and seven patients (participants of Prospective Urban Rural Epidemiology Study) took part in our study. The study group consisted of 31 patients with OSA (11 women and 20 men). Nine of them were diagnosed with mild OSA, nine with moderate OSA, and 13 with severe OSA. The control group consisted of 176 patients (133 women and 43 men) who scored 0–2 points in the STOP-BANG questionnaire. All patients underwent brain magnetic resonance imaging. We evaluated the occurrence and severity of WMHs.
Results:
Significantly higher incidence of WMHs was found in the study group compared to controls. In univariate analyses, age was a significant predictor of periventricular white matter changes. For subcortical area, age and waist-to-hip ratio were significant predictors.
Conclusions:
Significantly higher incidence of WMHs in the studied group suggests that patients with OSA may have a higher risk of neurodegeneration.
Changes typical for cerebral small vessel disease (i.a. white matter hyperintensities – WMHs) are often found accidentally in neuroimaging studies. Although asymptomatic, this condition increases the risk of future ischaemic incidents and neurodegenerative disorders. Sleep apnoea is a recognised risk factor for vascular diseases. The aim of our study was to assess the prevalence of, and association between, obstructive sleep apnea (OSA) and cerebral small vessel disease in the studied population.
Material and methods:
Two hundred and seven patients (participants of Prospective Urban Rural Epidemiology Study) took part in our study. The study group consisted of 31 patients with OSA (11 women and 20 men). Nine of them were diagnosed with mild OSA, nine with moderate OSA, and 13 with severe OSA. The control group consisted of 176 patients (133 women and 43 men) who scored 0–2 points in the STOP-BANG questionnaire. All patients underwent brain magnetic resonance imaging. We evaluated the occurrence and severity of WMHs.
Results:
Significantly higher incidence of WMHs was found in the study group compared to controls. In univariate analyses, age was a significant predictor of periventricular white matter changes. For subcortical area, age and waist-to-hip ratio were significant predictors.
Conclusions:
Significantly higher incidence of WMHs in the studied group suggests that patients with OSA may have a higher risk of neurodegeneration.
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