Prognostic value of TIMM50 expression in colorectal cancer
Bo Sun 1,   Jun Wang 2,   Yan-Feng Zhu 3,   Zhen-Yang Li 2,   Jian-Bin Xiang 2,   Zong-You Chen 2,   Zhi-Gang He 4,   Xiao-Dong Gu 2
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Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China 200032
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China 200040
Department of Nursing, Huashan Hospital, Fudan University, Shanghai, China 200040
Department of General Surgery, Shanghai Songjiang District Central Hospital, Shanghai, China 201600
Submission date: 2019-04-08
Final revision date: 2019-08-28
Acceptance date: 2019-09-12
Online publication date: 2020-04-15
Translocase of the inner mitochondrial membrane 50 (TIMM50) is universally considered to play a key role in several malignancies. However, its role in predicting colorectal cancer (CRC) patient prognosis remains unclear.

Material and methods:
A total of 192 CRC patients (123 men and 69 women) who underwent radical resection participated in this study. The patients were followed up every three months after surgery for five years. TIMM50 expression in tumour tissues was measured by quantitative real-time PCR, Western blotting and immunohistochemistry. TIMM50 expression was studied to assess correlations with clinicopathological factors and survival time.

TIMM50 expression increased significantly in CRC tumour tissues. Moreover, high TIMM50 expression was related to pathologic stage (p = 0.043), N stage (p = 0.048) and distant metastasis (p = 0.015), but TIMM50 expression was not related to other clinical factors. A Kaplan-Meier survival analysis indicated that patients with low TIMM50 expression had a longer overall survival than those with high TIMM50 expression (p = 0.002). Furthermore, distant metastasis and high TIMM50 expression were confirmed as independent prognostic factors for the overall survival of CRC patients in a multivariate analysis (p = 0.003).

TIMM50 may be a key factor for monitoring CRC and a new prog¬nosis indicator for CRC patients.