CLINICAL RESEARCH
Application of dexmedetomidine for lung injury in elderly patients undergoing one-lung ventilation
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1
Department of Anesthesiology, Beijing Chest Hospital, Capital Medical University, China
2
Department of Anesthesiology, Chinese PLA General Hospital, China
Submission date: 2019-03-22
Final revision date: 2019-08-28
Acceptance date: 2019-10-01
Online publication date: 2020-05-04
 
 
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ABSTRACT
Introduction:
This study aimed to evaluate the effects of dexmedetomidine (DEX) on lung injury, the oxygenation index and perioperative pulmonary complications in elderly patients who underwent thoracotomy with one-lung ventilation (OLV).

Material and methods:
A total of 120 elderly patients with lung cancer were included in the present study. According to the random number table method, these patients were randomly divided into two groups: group D and group C. Patients in group D were intravenously pumped with 0.5 µg/kg/h of DEX before anesthesia. The infusion was completed within 15 minutes, and anes¬thesia was induced by venous injection. Patients in group C were pumped with equal volumes of normal saline.

Results:
At T2 and T3, compared with group C, group D had a significant decrease in cardiac index, mean arterial pressure and central venous pressure (p < 0.05). At T2, T3 and T4, compared with group C, group D had a significant increase in pH and PaO2 (p < 0.05). At T2, T3 and T4, compared with group C, group D had a significant decrease in Qs/Qt (p < 0.05). At T6, compared with group C, group D had a significant decrease in the supernatant of bronchoalveolar lavage fluid of tumor necrosis factor-α and interleukin 6 (p < 0.05). At T5, compared with group C, group D had a significant decrease in Visual Analogue Scale score (p < 0.05), and a significant increase in Ramsay Sedation Scale score (p < 0.05), and the number of respiratory and cardiovascular events also decreased (p < 0.05).

Conclusions:
In elderly patients, dexmedetomidine can reduce Qs/Qt and increase PaO2 during OLV in surgery. It can reduce lung injury. Moreover, DEX reduced respiratory and cardiovascular complications in the perioperative period.

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ISSN:1734-1922