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PEDIATRICS / RESEARCH LETTER
Association of TMPRSS6 gene polymorphisms with severity of iron deficiency anemia in Uzbek schoolchildren: a molecular case-control study
1
Central Asian Medical University, Uzbekistan
2
Tashkent State Medical University, Uzbekistan
3
Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara City, Uzbekistan
These authors had equal contribution to this work
Submission date: 2026-04-24
Acceptance date: 2026-06-18
Online publication date: 2026-06-23
Corresponding author
Kamol I. Ibrohimov
Bukhara State Medical Institute named after Abu Ali ibn Sino Bukhara City, Uzbekistan
Bukhara State Medical Institute named after Abu Ali ibn Sino Bukhara City, Uzbekistan
Arch Med Sci 2026;22(3):1914-1917
TOPICS
REFERENCES (12)
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Benyamin B, Ferreira MR, Willemsen G, et al. Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet 2009; 41: 1173-5.
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Gichohi-Wainaina WN, Towers GW, Swinkels DW, Zimmermann MB, Feskens EJ, Melse-Boonstra A. Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses. Genes Nutr 2014; 10: 442.
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Silva NM, De Paiva Lopes M, Schincaglia RM, Coelho ASG, Cominetti C, Hadler MCCM. Anaemia and iron deficiency associate with polymorphism TMPRSS6 rs855791 in Brazilian children attending day care centres. Br J Nutr 2023; 131: 193-201.
8.
Buerkli S, Pei S, Hsiao S, et al. The TMPRSS6 variant (SNP rs855791) affects iron metabolism and oral iron absorption - a stable iron isotope study in Taiwanese women. Haematologica 2020; 106: 2897-905.
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Bhatia P, Singh A, Hegde A, Jain R, Bansal D. Systematic evaluation of paediatric cohort with iron refractory iron deficiency anaemia (IRIDA) phenotype reveals multiple TMPRSS6 gene variations. Br J Haematol 2017; 177: 311-8.
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Sharma A, Kumar A, Saha PK, Saha L. The role of TMPRSS6 gene polymorphism in iron resistance iron deficiency anaemia (IRIDA): a systematic review. Ann Hematol 2023; 103: 1085-102.
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El-Bostany EA, Elghoroury EA, Thabet EH, et al. Impact of TMPRSS6 gene polymorphism on iron overload among children with sickle cell disease. Hematol Oncol Stem Cell Ther 2025; 18: 108-14.
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Cadieux AH, Pham MK, Speckert M, Borkhoff CM, Parkin PC, Hamid JS. Interventions to treat pediatric iron deficiency anemia: a systematic review and meta-analysis. J Pediatr 2025; 289: 114898.
| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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