CARDIOLOGY / RESEARCH LETTER
Continuous positive airway pressure may improve hypertension in patients with obstructive sleep apnea-hypopnea syndrome by inhibiting inflammation and oxidative stress
| 1 | Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China |
| 2 | Health Management Center, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China |
| 3 | Sleep Medicine Center, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China |
| 4 | Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China |
CORRESPONDING AUTHOR
Gang Zhao
Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, No.324, Jing Wu Road, 250021, Jinan, China
Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, No.324, Jing Wu Road, 250021, Jinan, China
Submission date: 2022-09-16
Final revision date: 2022-11-02
Acceptance date: 2022-11-13
Online publication date: 2022-12-09
Publication date: 2023-01-01
Arch Med Sci 2023;19(1):237–241
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The work was designed to investigate the effect of continuous positive airway pressure (CPAP) on hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and to elucidate the underlying mechanisms.
Material and methods:
We examined the effect of CPAP on blood pressure and biomarkers reflecting inflammation and oxidative stress, and investigated the correlation between changes in blood pressure and the biomarkers.
Results:
CPAP significantly improved clinic, ambulatory and home blood pressure (p < 0.05). The hypotensive effect of CPAP was positively correlated with the decrease of interleukin-6, C-reactive protein, NADPH oxidase and malonaldehyde.
Conclusions:
CPAP has a significant antihypertensive effect on OSAHS patients, especially nocturnal hypertension, possibly by counteracting inflammation and oxidative stress.
The work was designed to investigate the effect of continuous positive airway pressure (CPAP) on hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and to elucidate the underlying mechanisms.
Material and methods:
We examined the effect of CPAP on blood pressure and biomarkers reflecting inflammation and oxidative stress, and investigated the correlation between changes in blood pressure and the biomarkers.
Results:
CPAP significantly improved clinic, ambulatory and home blood pressure (p < 0.05). The hypotensive effect of CPAP was positively correlated with the decrease of interleukin-6, C-reactive protein, NADPH oxidase and malonaldehyde.
Conclusions:
CPAP has a significant antihypertensive effect on OSAHS patients, especially nocturnal hypertension, possibly by counteracting inflammation and oxidative stress.
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