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RESEARCH LETTER
From GWAS to TWAS: multi-omics dissection of sepsis uncovers consistent impact of ATG4B across tissues
1
Department of Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, China
Submission date: 2025-12-02
Final revision date: 2026-01-01
Acceptance date: 2026-01-15
Online publication date: 2026-02-12
Corresponding author
Liuzhao Zhang
Department of Critical Care Medicine The Second Affiliated Hospital of Fujian Medical University China
Department of Critical Care Medicine The Second Affiliated Hospital of Fujian Medical University China
Deyuan You
Department of Critical Care Medicine The Second Affiliated Hospital of Fujian Medical University China
Department of Critical Care Medicine The Second Affiliated Hospital of Fujian Medical University China
TOPICS
REFERENCES (15)
1.
Lelubre C, Vincent JL. Mechanisms and treatment of organ failure in sepsis. Nat Rev Nephrol 2018; 14: 417-27.
2.
Cassini A, Allegranzi B, Fleischmann-Struzek C, et al. Global Report on the epidemiology and burden on sepsis: current evidence, identifying gaps and future directions. WHO 2020.
3.
Huang M, Cai S, Su J. The pathogenesis of sepsis and potential therapeutic targets. Int J Mol Sci 2019; 20: 5376.
4.
Guillen-Guio B, Lorenzo-Salazar JM, Ma SF, et al. Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. Lancet Respir Med 2020; 8: 258-66.
5.
Hu Y, Li M, Lu Q, et al. A statistical framework for cross-tissue transcriptome-wide association analysis. Nat Genet 2019; 51: 568-76.
6.
Sun R, Hui S, Bader GD, Lin X, Kraft P. Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic. PLoS Genet 2019; 15: e1007530.
7.
Wu C, Pan W. A powerful fine-mapping method for transcriptome-wide association studies. Human Genet 2020; 139: 199-213.
8.
Gusev A, Ko A, Shi H, et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet 2016; 48: 245-52.
9.
De Leeuw CA, Neale BM, Heskes T, Posthuma D. The statistical properties of gene-set analysis. Nat Rev Genet 2016; 17: 353-64.
10.
de Leeuw CA, Stringer S, Dekkers IA, Heskes T, Posthuma D. Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure. Nat Commun 2018; 9: 3768.
11.
Zhu Z, Zhang F, Hu H, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 2016; 48: 481-7.
12.
Agrotis A, Pengo N, Burden JJ, Ketteler R. Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells. Autophagy 2019; 15: 976-97.
13.
Maruyama T, Noda NN. Autophagy-regulating protease Atg4: structure, function, regulation and inhibition. J Antibiotics 2018; 71: 72-8.
14.
Satoo K, Noda NN, Kumeta H, et al. The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J 2009; 28: 1341-50.
15.
Dehaene H. THAP proteins in the transcriptional control of cell proliferation. Université de Lausanne, Faculté de biologie et médecine; 2019.
| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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