RESEARCH PAPER
Lipoprotein(a) in an adult sample from the Russian
population: distribution and association
with atherosclerotic cardiovascular diseases
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1 |
National Medical Research Center of Cardiology, Russia |
2 |
National Medical Research Center of Therapy and Preventive Medicine, Russia |
3 |
Lomonosov Moscow State University, Russia |
CORRESPONDING AUTHOR
Marat V Ezhov
National Medical Research Center of Cardiology, 3rd Cherepkovskaya street, 15a, 121552, Moscow, Russia
Submission date: 2020-10-11
Final revision date: 2020-11-18
Acceptance date: 2020-12-02
Online publication date: 2021-03-15
KEYWORDS
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ABSTRACT
Introduction:
Lipoprotein(a) (Lp(a)) is recognized as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD). The aim of this study
was to estimate the distribution of Lp(a) levels in working age adults from
the Russian population and to assess its association with ischemic heart
disease (IHD), myocardial infarction (MI), stroke, diabetes mellitus (DM), and
arterial hypertension (AH).
Material and methods:
This substudy of the population-based study “Epidemiology of Cardiovascular Diseases and their Risk Factors in Some Regions
of the Russian Federation” (ESSE-RF) included 8461 subjects aged 25–64
years (63.7% women) without lipid-lowering drugs. Atherosclerotic cardiovascular disease was self-reported. Lp(a), apolipoproteins AI and B, and lipid
and glucose levels in blood serum were determined.
Results:
The prevalence of Lp(a) ≥ 30 mg/dl was 20.5% and 23.0%, and prevalence of Lp(a) ≥ 50 mg/dl was 13.3% and 15.2%, in men and women, respectively. An association of Lp(a) with IHD, MI, and AH, but not with stroke
and DM, was shown. A cut-off level of Lp(a) of 9 mg/dl was determined,
above which there was increased frequency of MI (by 59.2%, p = 0.02), IHD
(by 33.4%, p < 0.001), and AH (by 11.6%, p < 0.001). In the multivariate
analysis only the association of Lp(a) with IHD (1.19 (1.01–1.41), p = 0.038)
and MI (1.57 (1.06–2.38), p = 0.028) remained significant.
Conclusions:
Lipoprotein(a) level ≥ 30 mg/dl was detected in every fifth
adult aged 25–64 years. Increased risk of MI and IHD starts at an Lp(a) serum level above 9 mg/dl.