ONCOLOGY / RESEARCH PAPER
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
In the present study, gold nanoparticles were prepared and synthesized in aqueous medium using V. thapsus leaf extract. We assessed the anti-human lung cancers potentials of these nanoparticles against well-differentiated bronchogenic adenocarcinoma, moderately differentiated adenocarcinoma of the lung, and poorly differentiated adenocarcinoma of the lung cell lines.

Material and methods:
AuNPs were characterized and analyzed by common nanotechnology techniques including FT-IR and UV-Vis. Spectroscopy, Field Emission-Scanning Electron Microscopy, and Transmission Electron Microscopy. For determining of anti-human lung cancer properties of HAuCl4, V. thapsus, and AuNPs, MTT assay was used on normal (HUVECs), well-differentiated bronchogenic adenocarcinoma (HLC-1), moderately differentiated adenocarcinoma of the lung (LC-2/ad), and poorly differentiated adenocarcinoma of the lung (PC-14) cell lines.

Results:
In the FT-IR test, the presence of many antioxidant compounds with related bonds caused the excellent condition for reducing of gold in the gold nanoparticles. In UV-Vis, the clear peak in the wavelength of 548 nm indicated the formation of gold nanoparticles. AuNPs had excellent anti-human lung cancer effects dose-dependently against HLC-1, LC-2/ad, and PC-14 cell lines. The best result of anti-human lung cancer activities of AuNPs against above cell lines was observed in the case of the PC-14 cell line.

Conclusions:
In conclusion, the synthesized AuNPs showed significant anti-human lung cancer properties against well-differentiated bronchogenic adenocarcinoma, moderately differentiated adenocarcinoma of the lung, and poorly differentiated adenocarcinoma of the lung cell lines in a dose depended on manner.

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ISSN:1734-1922