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ATHEROSCLEROSIS / RESEARCH LETTER
Polymorphism rs662 (Q192R) of paraoxonase-1 and susceptibility to atherosclerosis of the coronary arteries
1
Department of Hospital Pharmacy, Laboratory of Pharmacogenetics, Medical University of Lodz, Poland
2
Department of Pharmacology and Toxicology, Medical University of Lodz, Poland
Submission date: 2024-04-03
Final revision date: 2024-06-21
Acceptance date: 2024-08-13
Online publication date: 2024-08-26
Publication date: 2024-08-04
Corresponding author
Arch Med Sci 2024;20(4):1328-1333
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The present study concerns a connection of the Q192RPON1 polymorphism with atherosclerosis requiring percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the Polish population.
Material and methods:
A total of 282 individuals who underwent coronary angiography took part in this study. The polymorphism was determined with the PCR-RFLP method.
Results:
The odds ratio for atherosclerosis in carriers of the 192RR genotype was 2.50 (p = 0.002). The median HDL-C concentration was significantly lower in the study group than the control group (p = 0.02).
Conclusions:
The presence of the 192RR genotype and 192R allele are indicative of at least a two-fold increased risk of atherosclerosis requiring PCI or CABG in the Polish population.
The present study concerns a connection of the Q192RPON1 polymorphism with atherosclerosis requiring percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the Polish population.
Material and methods:
A total of 282 individuals who underwent coronary angiography took part in this study. The polymorphism was determined with the PCR-RFLP method.
Results:
The odds ratio for atherosclerosis in carriers of the 192RR genotype was 2.50 (p = 0.002). The median HDL-C concentration was significantly lower in the study group than the control group (p = 0.02).
Conclusions:
The presence of the 192RR genotype and 192R allele are indicative of at least a two-fold increased risk of atherosclerosis requiring PCI or CABG in the Polish population.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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