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Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges
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Submission date: 2013-10-28
Final revision date: 2013-11-17
Acceptance date: 2013-12-04
Online publication date: 2015-03-14
Publication date: 2015-02-28
Arch Med Sci 2015;11(1):57–66
Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their corresponding receptors (PDGFRs) are known as important regulators of blood vessel development in both normal and pathologic angiogenesis. Despite some recent papers which reported a potential role of the PDGF/PDGFR axis in lymphatic spread of tumor cells, a few papers have suggested the potential role of PDGFs in tumor lymphangiogenesis development. The present paper summarizes the potential lymphangiogenic role of the PDGF/PDGFR axis, underlying upcoming challenges in the field.