UROLOGY / SYSTEMATIC REVIEW/META-ANALYSIS
 
KEYWORDS
TOPICS
Urology
 
ABSTRACT
Introduction:
Worse survival in upper tract urothelial carcinoma (UTUC) in the presence of a tumour in the ureter vs. pelvicalyceal tumours is reported in some studies; however, the definition of ureteral involvement (UI) varies across studies. We systematically evaluated evidence regarding the prognostic role of UI in overall and cancer-specific survival of patients with UTUC.

Material and methods:
A systematic search of PubMed, Scopus and Web of Knowledge was performed in March 2018.

Results:
The results were presented as a comparison between ureteral vs. pelvicalyceal tumours. A total of 14,895 patients were identified. Cumulative analyses indicated that UI worsens cancer-specific survival (CSS) and overall survival (OS), with a pooled HR of 1.52 (p < 0.001) and 1.39 (p = 0.004), respectively.

Conclusion:
Our meta-analysis identified UI in UTUC as an adverse prognostic factor.

eISSN:1896-9151
ISSN:1734-1922