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PHARMACOLOGY AND PHARMACY / INVITED EDITORIAL
Beyond muscle: could GLP-1 receptor agonists offset the tendon risk of intensive lipid-lowering therapy?
1
PearResearch, Dehradun, India
2
Department of Cardiometabolic Medicine, Nobilis Institute of Cardiometabolic Excellence (NICE), Vigyaved Healthcare, Dehradun, India
3
Department of Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut, India
4
Department of Cardiology, Himachal Heart Institute, Mandi, Himachal Pradesh, India
5
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland
Submission date: 2026-08-02
Acceptance date: 2026-08-11
Online publication date: 2026-08-21
Corresponding author
Yashendra Sethi
Department of Cardiometabolic Medicine Nobilis Institute of Cardiometabolic Excellence (NICE), Vigyaved Healthcare Dehradun 248001, India Department of Medicine Subharti Medical College Swami Vivekanand Subharti University Meerut 250005, India
Department of Cardiometabolic Medicine Nobilis Institute of Cardiometabolic Excellence (NICE), Vigyaved Healthcare Dehradun 248001, India Department of Medicine Subharti Medical College Swami Vivekanand Subharti University Meerut 250005, India
TOPICS
REFERENCES (11)
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Seddio AE, Moran J, Gouzoulis MJ, et al. Lower risk of postoperative complications and rotator cuff retear associated with semaglutide use in patients with type ii diabetes mellitus undergoing arthroscopic rotator cuff repair. Arthroscopy 2025; 41: 199-206.
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Marie I, Delafenêtre H, Massy N, Thuillez C, Noblet C; Network of the French Pharmacovigilance Centers. Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990-2005 and review of the literature. Arthritis Rheum 2008; 59: 367-72.
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Eliasson P, Dietrich-Zagonel F, Lundin AC, Aspenberg P, Wolk A, Michaëlsson K. Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release – a cohort study design combined with an experimental study. Sci Rep 2019; 9: 17958.
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Tilley BJ, Cook JL, Docking SI, Gaida JE. Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review. Br J Sports Med 2015; 49: 1504-9.
7.
Bays HE, Bloedon LT, Lin G, et al. Safety of bempedoic acid in patients at high cardiovascular risk and with statin intolerance. J Clin Lipidol 2024; 18: e59-69.
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Bytyçi I, Penson PE, Mikhailidis DP, et al. Prevalence of statin intolerance: a meta-analysis. Eur Heart J 2022; 43: 3213-23.
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Serban MC, Colantonio LD, Manthripragada AD, et al. Statin intolerance and risk of coronary heart events and all-cause mortality following myocardial infarction. J Am Coll Cardiol 2017; 69: 1386-95.
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Neeland IJ, Linge J, Birkenfeld AL. Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies. Diabetes Obes Metab 2024; 26 Suppl 4: 16-27.
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Ceasovschih A, Asaftei A, Lupo MG, et al. Glucagon-like peptide-1 receptor agonists and muscle mass effects. Pharmacol Res 2025; 220: 107927.
| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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