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PHARMACOLOGY AND PHARMACY / INVITED EDITORIAL
Beyond muscle: could GLP-1 receptor agonists offset the tendon risk of intensive lipid-lowering therapy?
1
Subharti Medical College, India
2
PearResearch, India
3
Department of Cardiometabolism, Nobilis Institute of Cardiometabolic Excellence, Vigyaved Healthcare, India
4
Himachal Heart Institute: Mandi, Himachal Pradesh, IN, India
5
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland, Poland
Submission date: 2026-08-02
Acceptance date: 2026-08-03
Online publication date: 2026-08-03
TOPICS
REFERENCES (11)
1.
Khayyat MY, Khayyat YM. The effect of GLP-1 receptor agonists on tendon and ligament healing: a systematic review and meta-analysis. Arch Med Sci 2026; in press.
2.
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3.
Seddio AE, Moran J, Gouzoulis MJ, et al. Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated With Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair. Arthroscopy. 2025;41(2):199-206. doi:10.1016/j.arthro.2024.09.057.
4.
Marie I, Delafenêtre H, Massy N, Thuillez C, Noblet C; Network of the French Pharmacovigilance Centers. Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990-2005 and review of the literature. Arthritis Rheum. 2008;59(3):367-372. doi:10.1002/art.23309.
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Eliasson P, Dietrich-Zagonel F, Lundin AC, Aspenberg P, Wolk A, Michaëlsson K. Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release - a cohort study design combined with an experimental study. Sci Rep. 2019;9(1):17958. Published 2019 Nov 29. doi:10.1038/s41598-019-53238-7.
6.
Tilley BJ, Cook JL, Docking SI, Gaida JE. Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review. Br J Sports Med. 2015;49(23):1504-1509. doi:10.1136/bjsports-2015-095100.
7.
Bays HE, Bloedon LT, Lin G, et al. Safety of bempedoic acid in patients at high cardiovascular risk and with statin intolerance. J Clin Lipidol. 2024;18(1):e59-e69. doi:10.1016/j.jacl.2023.10.011.
8.
Bytyçi I, Penson PE, Mikhailidis DP, et al. Prevalence of statin intolerance: a meta-analysis. Eur Heart J. 2022;43(34):3213-3223. doi:10.1093/eurheartj/ehac015.
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Serban MC, Colantonio LD, Manthripragada AD, et al. Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction. Journal of the American College of Cardiology. 2017 Mar;69(11):1386-1395. DOI: 10.1016/j.jacc.2016.12.036.
10.
Neeland IJ, Linge J, Birkenfeld AL. Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies. Diabetes Obes Metab. 2024;26 Suppl 4:16-27. doi:10.1111/dom.15728.
11.
Ceasovschih A, Asaftei A, Lupo MG, Kotlyarov S, Bartušková H, Balta A, Sorodoc V, Sorodoc L, Banach M. Glucagon-like peptide-1 receptor agonists and muscle mass effects. Pharmacol Res. 2025 Oct;220:107927. doi: 10.1016/j.phrs.2025.107927.
| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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