CLINICAL RESEARCH
Effect of atorvastatin on delirium status of patients in the intensive care unit: a randomized controlled trial
 
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1
Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2
Stroke Prevention & Atherosclerosis Research Centre, University of Western Ontario, Canada
3
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shahid Sadoughi University of Medical Silences, Yazd, Iran
4
Department of Anesthesia and Intensive Care Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6
Department of Biostatistics and Epidemiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7
Department of Clinical Neurological Sciences, University of Western Ontario, Canada
8
Department of Epidemiology and Biostatistics, University of Western Ontario, Canada
9
Department of Psychology, Science and Arts University, Yazd, Iran
10
Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland
11
Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
12
Halal Research Center of IRI, FDA, Tehran, Iran
13
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
14
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
15
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
16
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Submission date: 2019-09-29
Acceptance date: 2019-09-29
Online publication date: 2019-11-12
 
 
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ABSTRACT
Introduction:
Delirium is one of the most prevalent complications in intensive care unit (ICU) patients, which is related to worse clinical outcomes including a longer ICU stay, longer duration of mechanical ventilation, higher mortality rates and increased risk of cognitive impairment. Observational studies have suggested that statins might have a positive effect on delirium status of hospitalized patients. To date, there has been no trial assessing the effect of atorvastatin on delirium status in critically ill patients. Thus, the aim of the current study was to determine the efficacy of atorvastatin on delirium status of patients in the ICU.

Material and methods:
In this randomized, double-blind and controlled trial, a total of 90 patients in the general ICU who had delirium for at least 2 days were randomly divided into atorvastatin (40 mg/day) (n = 40) and control (n = 50) groups. Delirium status of the patients was determined twice a day at 10:00 a.m. and 18:00 p.m. using the Richmond Agitation-Sedation Scale (RASS).

Results:
Administration 40 mg/day of atorvastatin significantly reduced the mean RASS score and increased delirium-free days at both morning and afternoon time points compared to the control group (p < 0.05).

Conclusions:
Administration of atorvastatin had a significant positive effect on delirium status in patients admitted to the ICU.

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ISSN:1734-1922