OBSTETRICS AND GYNAECOLOGY / RESEARCH PAPER
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
To systematically analyze the associations of perinatal disease activity with adverse outcomes of Chinese patients with systemic lupus erythematosus (SLE) and their offspring.

Material and methods:
Data of prenatal SLE patients and healthy pregnant woman admitted to our hospital during October 2001 to January 2018 were retrospectively collected, and the status of SLE offspring was followed-up in March 2020. Disease activity was evaluated by SLE disease activity index 2000 (SLEDAI-2k), and those with scores > 6 were defined as having active disease.

Results:
Totally 198 deliveries of 194 SLE patients and 199 deliveries of healthy women were documented. Maternal and fetal adverse outcomes occurred in 74 (37.4%) and 90 (45.5%) deliveries of SLE patients respectively, which was significantly higher than those of healthy subjects. Among SLE patients, the active group had higher rates of gestational hypertension (p<0.001), preeclampsia/eclampsia (p<0.001), low birth weight (p<0.001), premature birth (p<0.001) and fetal growth restriction (FGR) (p<0.01) than inactive group. Multivariate logistic analysis revealed that perinatal renal activity was associated with gestational hypertension (OR 4.43, p<0.001), preeclampsia/ eclampsia (OR 9.14, p<0.001), low birth weight (OR 2.24, p<0.05) and premature birth (OR 4.20, p<0.001). Compared with the general population, SLE offspring had relatively high rates of eczema (50/142 35.2%) and congenital heart disease (6/142 4.2%), which were irrelevant to perinatal disease activity, but related to specific antibodies.

Conclusions:
For perinatal SLE women, renal activity is associated with a variety of adverse pregnancy outcomes. However, maternal perinatal disease activity does not seem to affect the growth of their offspring.

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ISSN:1734-1922