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RHEUMATOLOGY / CLINICAL RESEARCH
Women suffering from systemic lupus erythematosus are characterized by low blood levels of α-dicarbonyl compounds
1
Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poland
2
2nd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poland
Submission date: 2023-10-05
Final revision date: 2023-12-12
Acceptance date: 2023-12-13
Online publication date: 2024-01-31
Corresponding author
Aleksandra Damasiewicz-Bodzek
Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poland
Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poland
Arch Med Sci 2024;20(3):743-750
KEYWORDS
TOPICS
Allergology and ImmunologyBiochemistryBiology, MolecularRheumatologyDiffuse Diseases of Connective TissueFamilial Mediterranean Fever and other Systemic Autoinflammatory DiseasesAutoimmunity
ABSTRACT
Introduction:
Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease, often characterised by severe course and unclear etiopathogenesis. The reaction of protein glycoxidation, also known as glycation, may be linked to etiopathogenesis of SLE. Advanced glycation end-products (AGEs) exhibit cytotoxic properties, affect cellular signalling, impair functions of extracellular proteins, and may act as neoepitopes. Glucosone (GS), glyoxal (GO), and methylglyoxal (MGO) are examples of α-dicarbonyl compounds (α-DCs) partaking in glycoxidation. The study aimed to evaluate concentrations of these three compounds in blood serum of SLE patients, and to compare the results with healthy individuals.
Material and methods:
31 women suffering from SLE and 26 healthy individuals were included in the study. High-performance liquid chromatography with fluorescence detection was applied to evaluate concentrations of α-DCs in their serum samples. Correlations between the results and parameters such as disease duration time, age, glomerular filtration rate (GFR), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and creatinine were analysed.
Results:
The SLE patients exhibited lower concentrations of glucosone, glyoxal, and methylglyoxal than the control group. Analysis of correlations showed a difference between the examined groups.
Conclusions:
In women suffering from SLE the course of α-DCs metabolism is altered. SLE patients are characterised by low serum levels of α-DCs. We hypothesise that either hindered proteasomal degradation or fast consumption of α-DCs in oxidative conditions may cause the observed low concentration of these compounds.
Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease, often characterised by severe course and unclear etiopathogenesis. The reaction of protein glycoxidation, also known as glycation, may be linked to etiopathogenesis of SLE. Advanced glycation end-products (AGEs) exhibit cytotoxic properties, affect cellular signalling, impair functions of extracellular proteins, and may act as neoepitopes. Glucosone (GS), glyoxal (GO), and methylglyoxal (MGO) are examples of α-dicarbonyl compounds (α-DCs) partaking in glycoxidation. The study aimed to evaluate concentrations of these three compounds in blood serum of SLE patients, and to compare the results with healthy individuals.
Material and methods:
31 women suffering from SLE and 26 healthy individuals were included in the study. High-performance liquid chromatography with fluorescence detection was applied to evaluate concentrations of α-DCs in their serum samples. Correlations between the results and parameters such as disease duration time, age, glomerular filtration rate (GFR), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and creatinine were analysed.
Results:
The SLE patients exhibited lower concentrations of glucosone, glyoxal, and methylglyoxal than the control group. Analysis of correlations showed a difference between the examined groups.
Conclusions:
In women suffering from SLE the course of α-DCs metabolism is altered. SLE patients are characterised by low serum levels of α-DCs. We hypothesise that either hindered proteasomal degradation or fast consumption of α-DCs in oxidative conditions may cause the observed low concentration of these compounds.
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