Systematic review/Meta-analysis
The incidence of acute myocardial infarction in relation to overweight and obesity: a meta-analysis
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Submission date: 2013-11-19
Final revision date: 2014-01-13
Acceptance date: 2014-02-10
Online publication date: 2014-10-23
Publication date: 2014-10-31
Arch Med Sci 2014;10(5):855-862
Introduction: Epidemiological evidence suggests that overweight and obesity have been associated with acute myocardial infarction (AMI). However, data on this issue are controversial. This study aims to use meta-analysis to determine whether overweight and obesity are related to AMI.
Material and methods: We searched PubMed and Embase databases up to October 23rd, 2013 for related literature. The association of overweight and obesity with AMI was assessed by odd ratio (OR) with 95% confidence interval (CI) as the effect size. Then subgroup analysis was performed according to gender, area and study type.
Results: Five primary studies (one cohort study and four case-control studies) were included in this meta-analysis involving 36 803 participants, 14 883 of whom had an AMI. There was a significant association between overweight and AMI (OR = 1.27, 95% CI: 1.21–1.33, p < 0.001). Similar results revealed a relation between obesity and AMI (OR = 1.22, 95% CI: 1.07–1.40, p = 0.003). Subgroup analysis showed that overweight and obesity were positively associated with AMI risk except for obese subjects in Europe. There was no publication bias (Begg’s test p = 0.972, Egger’s test p = 0.858).
Conclusions: Both overweight and obesity increased the incidence of AMI, and it is necessary to control weight to prevent AMI. A large number of studies is needed to explore the mechanisms that link overweight and obesity with AMI.
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