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ONCOLOGY / RESEARCH LETTER
Telomeres and telomerase in endometrial cancer and hyperplasia
1
Institute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Opole, Poland
2
Independent Laboratory of Cancer Diagnostics and Immunology, Medical University of Lublin, Lublin, Poland
Submission date: 2024-01-05
Final revision date: 2024-02-21
Acceptance date: 2024-03-17
Online publication date: 2024-03-30
Arch Med Sci 2024;20(2):682-685
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.
Material and methods:
Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.
Results:
The control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.
Conclusions:
Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.
The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.
Material and methods:
Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.
Results:
The control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.
Conclusions:
Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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