HEPATOLOGY / RESEARCH PAPER
Association between Cluster of Differentiation 24 (CD24) Polymorphism, Talin-1 gene expression and Hepatocellular Carcinoma prevalence in Egyptian population
| 1 | Department of Biochemistry, Faculty of Pharmacy, Ahram Canadian University, Egypt |
| 2 | Department of Microbiology and Immunology, Faculty of Pharmacy, October 6 University (O6U), Egypt |
| 3 | Department of Histology, Faculty of Medicine, October 6 University (O6U), Egypt |
| 4 | Department of Biochemistry, Faculty of Pharmacy, Modern Sciences and Arts University (MSA), October 6 City, Giza, Egypt., Egypt |
CORRESPONDING AUTHOR
Sherine Ibrahim
Department of Biochemistry, Faculty of Pharmacy, Modern Sciences and Arts University (MSA), October 6 City, Giza, Egypt., Egypt
Department of Biochemistry, Faculty of Pharmacy, Modern Sciences and Arts University (MSA), October 6 City, Giza, Egypt., Egypt
Submission date: 2020-10-17
Final revision date: 2021-07-08
Acceptance date: 2021-07-23
Online publication date: 2021-08-13
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Background: Hepatitis C is considered as one of the most popular diseases in Egypt. Our aim is to clarify the association between Cluster of Differentiation 24 (CD24) polymorphism, Talin-1 gene expression and the prevalence of hepatocellular carcinoma in Egyptian Hepatitis C virus patients.
Material and methods:
The link between CD24 polymorphism rs8734 and the prevalence of hepatocellular carcinoma was assessed between 200 control subjects and 400 hepatitis C virus patients (HCV), patients were classified as follows; 200 patients with HCV and 200 with HCV and hepatocellular carcinoma (HCC) by histopathological assessment and PCR-restriction fragment length polymorphism (PCR-RFLP).
Results:
Results: The hepatitis c patients with HCC showed significant increase in alpha fetoprotein (AFP) and Talin-1 gene expression compared to patients with HCV as well as in healthy volunteers. Furthermore, the frequencies of CD 24 170 CT/TT genotype were significantly higher in HCV patients without complications (60%) when compared to CC genotype (40%) (OR= 6 at X2= 14.41, P = 0.0007), and in HCV with HCC patients (90%) when compared to CC genotype (10%) (OR= 36 at X2= 14.41, P = 0.0007).
Conclusions:
These data suggests that CD24 genetic polymorphism rs8734 and Talin-1 gene expression may be a significant determinant for the prevalence of hepatocellular carcinoma in HCV patients.
Background: Hepatitis C is considered as one of the most popular diseases in Egypt. Our aim is to clarify the association between Cluster of Differentiation 24 (CD24) polymorphism, Talin-1 gene expression and the prevalence of hepatocellular carcinoma in Egyptian Hepatitis C virus patients.
Material and methods:
The link between CD24 polymorphism rs8734 and the prevalence of hepatocellular carcinoma was assessed between 200 control subjects and 400 hepatitis C virus patients (HCV), patients were classified as follows; 200 patients with HCV and 200 with HCV and hepatocellular carcinoma (HCC) by histopathological assessment and PCR-restriction fragment length polymorphism (PCR-RFLP).
Results:
Results: The hepatitis c patients with HCC showed significant increase in alpha fetoprotein (AFP) and Talin-1 gene expression compared to patients with HCV as well as in healthy volunteers. Furthermore, the frequencies of CD 24 170 CT/TT genotype were significantly higher in HCV patients without complications (60%) when compared to CC genotype (40%) (OR= 6 at X2= 14.41, P = 0.0007), and in HCV with HCC patients (90%) when compared to CC genotype (10%) (OR= 36 at X2= 14.41, P = 0.0007).
Conclusions:
These data suggests that CD24 genetic polymorphism rs8734 and Talin-1 gene expression may be a significant determinant for the prevalence of hepatocellular carcinoma in HCV patients.
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