ATHEROSCLEROSIS / RESEARCH LETTER
Association between Lp(a) and T2D: A Mendelian Randomization Study
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1
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
2
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Poland
3
Ciccarone Center for the Prevention of Cardiovascular Disease, School of Medicine, Johns Hopkins University, United States
4
Department of Family Medicine and Public Health, University of Opole, Poland
5
Department of Cardiology, University Hospital, Institute of Medical Sciences, University of Opole, Poland
Submission date: 2024-04-09
Final revision date: 2024-04-19
Acceptance date: 2024-04-20
Online publication date: 2024-04-20
Corresponding author
Mateusz Lejawa
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
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ABSTRACT
Introduction:
Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian Randomization (MR) study, the causal impact of genetically-predicted Lp(a) on T2D was assessed.
Material and methods:
A two-sample MR analysis was conducted. Data were obtained from UKBiobank and FinnGen consortia. Primary analysis was based on inverse-variance-weighted mean (IVM) approach.
Results:
No statistically significant association between the genetically predicted levels of Lp(a) and T2D was detected (p=0.362) in IVM analysis involving data of 563,420 patients.
Conclusions:
Genetically predicted Lp(a) concentration does not appear to causally influence the risk of T2D.