CLINICAL RESEARCH
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in Poland: analysis of patient series and practical guidelines for breast surgeons
 
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1
Department of Surgical Oncology and Breast Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
2
Department of Hematology, Jagiellonian University Medical College, Krakow, Poland
3
Klinika Kolasinski, Swarzedz, Poland
4
Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
5
Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
6
Department of Radiotherapy, Military Institute of Medicine, Warsaw, Poland
7
Department of Radiology, Regional Oncology Centre, Copernicus Memorial Hospital, Lodz, Poland
8
Legal Advisor’s Office, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
9
Department of Radiotherapy and General Oncology, Regional Oncology Centre, Copernicus Memorial Hospital in Lodz, Medical University of Lodz, Lodz, Poland
10
Private Practice Lubomir Lembas, Warsaw, Poland
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Department of Experimental Hematology, Medical University of Lodz, Lodz, Poland
12
Department of Hematology, Medical University of Lodz, Lodz, Poland
13
Departament of Gynecology and Oncology, Jagiellonian University, Medical College Breast Unit of University Hospital, Krakow, Poland
14
Department of Head and Neck Cancer Surgery, Breast Cancer Unit, Medical University of Lodz, Lodz, Poland
15
Clinic of General Surgery and Surgical Oncology, Faculty of Medicine and Health Sciences University, Zielona Gora, Poland
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Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
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Department of Plastic Surgery, Gdansk Medical University, Gansk, Poland
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Dr Maciej Kuczyński Plastic Surgery Center, Lublin, Poland
19
Department of Oncology, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
Submission date: 2020-07-12
Final revision date: 2020-09-07
Acceptance date: 2020-09-07
Online publication date: 2020-11-05
 
 
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ABSTRACT
Introduction:
Although breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is infrequent, with less than 1000 noted cases worldwide, patients consenting for breast implant surgery should be aware of its risk. We describe the first Polish multicenter case-series data on BIA-ALCL patients and present diagnostic and treatment recommendation for breast surgeons.

Material and methods:
In cooperation with the Polish Society of Surgical Oncology and Polish Lymphoma Research Group, we collected BIA-ALCL cases in Poland.

Results:
We retrospectively reviewed clinical data of seven BIA-ALCL patients, diagnosed between July 2013 and November 2019. The median time from implant placement to the first BIA-ALCL symptoms was 65 months (range: 33–96 months). All the patients were exposed to textured implants at presentation. Capsulectomy with implant removal was performed in all the patients with immediate reimplantation in 2 cases. In a median follow-up of 19 months (range 5-81 months), there was no recurrence and all the patients stayed alive. Between 2013 and 2019, the incidence of BIA-ALCL in Polish female population age 30 and above ranged from 0 to 0.021/100 000/year.

Conclusions:
BIA-ALCL is scarce in the Polish population. In a short-term follow-up, patients’ prognosis remains excellent. Due to the withdrawal of roughly textured implants from the market and the exclusion of likely the most potent etiologic factor, it might be expected that the incidence of BIA-ALCL will become even rarer.

eISSN:1896-9151
ISSN:1734-1922