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INFECTIOUS DISEASES / CLINICAL RESEARCH
The role of vaccination, testing, and public restriction policies in COVID-19 mortality and incidence: insights from Global Burden of Disease regions
1
Division of Health Administration, Yonsei University, Wonju, Republic of Korea
2
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
Submission date: 2024-03-25
Final revision date: 2024-07-15
Acceptance date: 2024-07-24
Online publication date: 2024-08-05
Corresponding author
Myung-Bae Park
Department of Internal Medicine, Yonsei University, Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Republic of Korea
Department of Internal Medicine, Yonsei University, Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Republic of Korea
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This study aimed to examine the impacts of vaccination, testing, and government policies on COVID-19 mortality and incidence rates and compare these strategies’ effectiveness across the seven super regions of the Global Burden of Disease (GBD) study.
Material and methods:
This study used data from January 3, 2020, to March 29, 2023. The incidence and mortality indices were calculated using “daily cases” and “daily deaths” and selected as dependent variables. Vaccination, COVID-19 tests, and strictness of a government’s policy were explored using corresponding metrics.
Results:
Daily cases were four times higher in the high-income (HI) region (371.1) than those in the Latin America and Caribbean region (98.3), but the mortality rate was similar (1.5). The number of vaccinated people did not consistently reduce the mortality across all GBD regions. However, full vaccination was associated with decreased mortality in all regions except Central, Eastern, and Southeastern Europe and Central Asia (CEEECA). Regarding daily testing, a favorable correlation was observed between daily deaths on a global scale, excluding Southeast Asia, East Asia, and Oceania. Overall, vaccination coverage and government policies were effective in reducing COVID-19 mortality and incidence rates. However, only the HI region showed a negative association between the COVID-19 stringency index and both incidence and mortality rates.
Conclusions:
Full vaccination significantly reduced COVID-19 mortality globally, except in the CEEECA region. The HI region showed lower incidence and mortality rates with stricter government measures. Effective vaccination programs and policies are crucial, emphasizing the need for strengthened international cooperation in future pandemics.
This study aimed to examine the impacts of vaccination, testing, and government policies on COVID-19 mortality and incidence rates and compare these strategies’ effectiveness across the seven super regions of the Global Burden of Disease (GBD) study.
Material and methods:
This study used data from January 3, 2020, to March 29, 2023. The incidence and mortality indices were calculated using “daily cases” and “daily deaths” and selected as dependent variables. Vaccination, COVID-19 tests, and strictness of a government’s policy were explored using corresponding metrics.
Results:
Daily cases were four times higher in the high-income (HI) region (371.1) than those in the Latin America and Caribbean region (98.3), but the mortality rate was similar (1.5). The number of vaccinated people did not consistently reduce the mortality across all GBD regions. However, full vaccination was associated with decreased mortality in all regions except Central, Eastern, and Southeastern Europe and Central Asia (CEEECA). Regarding daily testing, a favorable correlation was observed between daily deaths on a global scale, excluding Southeast Asia, East Asia, and Oceania. Overall, vaccination coverage and government policies were effective in reducing COVID-19 mortality and incidence rates. However, only the HI region showed a negative association between the COVID-19 stringency index and both incidence and mortality rates.
Conclusions:
Full vaccination significantly reduced COVID-19 mortality globally, except in the CEEECA region. The HI region showed lower incidence and mortality rates with stricter government measures. Effective vaccination programs and policies are crucial, emphasizing the need for strengthened international cooperation in future pandemics.
REFERENCES (51)
1.
Nicola M, Alsafi Z, Sohrabi C, et al. The socio-economic implications of the coronavirus pandemic (COVID-19): a review. Int J Surg 2020; 78: 185-93.
2.
Chen CWS, So MKP, Liu FC. Assessing government policies’ impact on the COVID-19 pandemic and elderly deaths in East Asia. Epidemiol Infect 2022; 150: e161.
3.
Haas EJ, Angulo FJ, McLaughlin JM, et al. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet 2021; 397: 1819-29.
4.
Halim M, Halim A, Tjhin Y. COVID-19 vaccination efficacy and safety literature review. J Clin Med Res 2021; 3: 1-10.
5.
Le TT, Cramer JP, Chen R, Mayhew S. Evolution of the COVID-19 vaccine development landscape. Nat Rev Drug Discov 2020; 19: 667-8.
6.
Lazarus JV, Wyka K, White TM, et al. A survey of COVID-19 vaccine acceptance across 23 countries in 2022. Nat Med 2023; 29: 366-75.
7.
Levine R. Preventing hib disease in Chile and the Gambia. In: Case studies in global health: millions saved. Levine R (ed.). Jones & Bartlett Publishers 2007; 147-54.
8.
Mercer TR, Salit M. Testing at scale during the COVID-19 pandemic. Nat Rev Genet 2021; 22: 415-26.
9.
Chen AT, Ryskina KL, Jung HY. Long-term care, residential facilities, and COVID-19: an overview of federal and state policy responses. J Am Med Dir Assoc 2020; 21: 1186-90.
10.
Shvetsova O, Zhirnov A, Giannelli FR, et al. Governor’s party, policies, and COVID-19 outcomes: further evidence of an effect. Am J Prev Med 2022; 62: 433-7.
11.
Spiliopoulos L. On the effectiveness of COVID-19 restrictions and lockdowns: pan metron ariston. BMC Public Health 2022; 22: 1842.
12.
Herby J, Jonung L, Hanke S. A literature review and meta-analysis of the effects of lockdowns on COVID-19 mortality-II. Munich Personal RePEc Archive Paper No. 113732, 2022.
13.
Joffe AR, Redman D. The SARS-CoV-2 pandemic in high income countries such as canada: a better way forward without lockdowns. Front Public Health 2021; 9: 715904.
15.
Murray CJL. The global burden of disease study at 30 years. Nat Med 2022; 28: 2019-26.
16.
Ranabhat CL, Jakovljevic M, Kim CB, Simkhada P. COVID-19 pandemic: an opportunity for universal health coverage. Front Public Health 2021; 9: 673542.
17.
Ranabhat CL, Jakovljevic M, Dhimal M, Kim CB. Structural factors responsible for universal health coverage in low- and middle-income countries: results from 118 countries. Front Public Health 2019; 7: 414.
18.
Mathieu E, Ritchie H, Ortiz-Ospina E, et al. A global database of COVID-19 vaccinations. Nat Human Behav 2021; 5: 947-53.
19.
IAPB. About GBD regions and super regions. 2023; Available from: https://www.iapb.org/learn/vis....
21.
Kropko J, Kubinec R. Interpretation and identification of within-unit and cross-sectional variation in panel data models. PLoS One 2020; 15: e0231349.
22.
Zeitoun JD, Faron M, Lefevre JH. Impact of the local care environment and social characteristics on aggregated hospital fatality rate from COVID-19 in France: a nationwide observational study. Public Health 2020; 189: 104-9.
23.
Bauer J, Bruggmann D, Klingelhofer D, et al. Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19. Intensive Care Med 2020; 46: 2026-34.
24.
Mremi IR, George J, Rumisha SF, et al. Twenty years of integrated disease surveillance and response in Sub-Saharan Africa: challenges and opportunities for effective management of infectious disease epidemics. One Health Outlook 2021; 3: 22.
25.
Apeagyei A, Dieleman J, Leachkemon K. Financing Global Health 2023: The Future of Health Financing in the Post-Pandemic Era. 2024, Financing Global Health 2023: The Future of Health Financing in the Post-Pandemic Era: Seattle, WA.
26.
Jayatilleke K. Challenges in implementing surveillance tools of high-income countries (HICs) in low middle income countries (LMICs). Curr Treat Options Infect Dis 2020; 12: 191-201.
27.
Ioannidis JP. Over-and under-estimation of COVID-19 deaths. Eur J Epidemiol 2021; 36: 581-8.
28.
Bradshaw D, Dorrington R, Moultrie T, et al. Underestimated COVID-19 mortality in WHO African region. Lancet Glob Health 2022; 10: e1559.
29.
Moyo E, Mhango M, Moyo P, et al. Emerging infectious disease outbreaks in Sub-Saharan Africa: learning from the past and present to be better prepared for future outbreaks. Front Public Health 2023; 11: 1049986.
30.
Zhou YR. Vaccine nationalism: contested relationships between COVID-19 and globalization. Globalizations 2022; 19: 450-65.
32.
Dyer O. Covid vaccines: Canada to dispose of 13.6 million AstraZeneca doses owing to lack of demand. BMJ 2022; 378: o1700.
33.
Gupta A. COVAX can still end COVID-19 vaccine apartheid. Nat Human Behav 2022; 6: 175.
34.
Deaton AS, Tortora R. People in sub-Saharan Africa rate their health and health care among the lowest in the world. Health Affairs 2015; 34: 519-27.
35.
Diop BZ, Ngom M, Biyong CP, Biyong JNP. The relatively young and rural population may limit the spread and severity of COVID-19 in Africa: a modelling study. BMJ Global Health 2020; 5: e002699.
36.
Adams J, MacKenzie MJ, Amegah AK, et al. The conundrum of low COVID-19 mortality burden in sub-Saharan Africa: myth or reality? Global Health Sci Pract 2021; 9: 433-43.
37.
Suthar AB, Wang J, Seffren V, et al. Public health impact of covid-19 vaccines in the US: observational study. BMJ 2022; 377: e069317.
38.
McLaughlin JM, Khan F, Pugh S, et al. County-level vaccination coverage and rates of COVID-19 cases and deaths in the United States: an ecological analysis. Lancet Reg Health Am 2022; 9: 100191.
39.
Watson OJ, Barnsley G, Toor J, et al. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis 2022; 22: 1293-302.
40.
Park MB, Sim B. Vaccine effectiveness of COVID-19 and rebound in the real world. Clin Exp Med 2023; 23: 4975-83.
41.
Moghadas SM, Vilches TN, Zhang K, et al. The impact of vaccination on coronavirus disease 2019 (COVID-19) outbreaks in the United States. Clin Infect Dis 2021; 73: 2257-64.
42.
Suryawanshi YN, Biswas DA. Herd Immunity to fight against COVID-19: a narrative review. Cureus 2023; 15: e33575.
43.
Lyke KE, Atmar RL, Islas CD, et al. Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant. Cell Rep Med 2022; 3: 100679.
44.
Chi WY, Li YD, Huang HC, et al. COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection. J Biomed Sci 2022; 29: 82.
45.
Andrews N, Stowe J, Kirsebom F, et al. Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England. Nat Med 2022; 28: 831-7.
46.
Park MB, Ranabhat CL. COVID-19 trends, public restrictions policies and vaccination status by economic ranking of countries: a longitudinal study from 110 countries. Arch Public Health 2022; 80: 197.
47.
Leffler CT, Ing E, Lykins JD, et al. Association of country-wide coronavirus mortality with demographics, testing, lockdowns, and public wearing of masks. Am J Trop Med Hyg 2020; 103: 2400-11.
48.
Wei C, Lee CC, Hsu TC, et al. Correlation of population mortality of COVID-19 and testing coverage: a comparison among 36 OECD countries. Epidemiol Infect 2020; 149: e1.
49.
Dhama K, Nainu F, Frediansyah A, et al. Global emerging Omicron variant of SARS-CoV-2: impacts, challenges and strategies. J Infect Public Health 2023; 16: 4-14.
50.
Tsigaris P, Teixeira da Silva JA. Smoking prevalence and COVID-19 in Europe. Nicotine Tob Res 2020; 22: 1646-9.
51.
Martins-Filho PR. Relationship between population density and COVID-19 incidence and mortality estimates: a county-level analysis. J Infect Public Health 2021; 14: 1087.
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