Clinical study on prevention of atopic dermatitis by oral administration of probiotics in infants
Jia-huan He 1,   Xin-guo Zhao 2,   Feng Sun 2,   Wen-qi Peng 2,   Huan-yun Li 2,   Hui Li 2
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Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
Department of Taian, The 960 Hospital of the PLA, Taian, Shandong, China
Submission date: 2020-06-17
Final revision date: 2020-09-09
Acceptance date: 2020-09-19
Online publication date: 2020-11-05
This study aimed to investigate the preventive effects of oral administration of probiotics on the incidence and severity of atopic dermatitis (AD) in infants.

Material and methods:
A total of 396 full-term infants were enrolled in this study. Of these, 132 newborns without a family history of AD were assigned to group A, and the other 264 newborns were randomly divided into groups B and C. Infants in groups A and B were solely breastfed, while probiotics were administered to those in group C as well as breastfeeding. The information of all subjects was recorded, and the incidence of AD was followed up. The levels of serum IgE and IL-4 were measured at the age of 3 years.

The incidence of AD in infants in group B was higher than that in group A at 3 months, 4–6 months, and 7–36 months after birth, together with increased symptom scores. For infants in group C, the incidence of AD at 4–6 months and 7–36 months after birth and the SCORAD scores at 0–3 months and 4–6 months after birth were lower than those in group B. The levels of IgE and IL-4 in group B were higher than those in groups A and C at 36 months old.

Adding probiotics could favor the establishment of the intestinal microecological balance in the neonatal period, thereby reducing the incidence of AD, decreasing the levels of serum immune indexes and alleviating the severity of the disease.