Introduction: Amantadine is a well-known medication with indications in neurology and infectious diseases. It is currently FDA approved for Parkinson disease, drug induced extrapyramidal symptoms, and influenza.
Material and methods: The article is author's original research hypothesis.
Results: As more people are going to be vaccinated and more similar vaccines are going to be introduced, we should take into consideration a potential of amantadine to interfere with LNP-mRNA COVID-19 vaccine delivery into the target cells.
Conclusions: A more cautious approach to the patients taking amantadine as far as vaccination utilizing LNP-mRNA platform should be considered.