CLINICAL RESEARCH
Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies
 
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1
Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Opole, Poland
2
Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
3
Chair of Family Medicine, Jagiellonian University Medical College, Krakow, Poland
4
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
5
Mastej Medical Centre, Jasło, Poland
6
Department of Pharmacological Sciences University of Milano and Multimedica IRCCS, Milano, Italy
7
Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College, Kensington, London, UK
8
Department of Clinical Biochemistry, Royal Free Hospital, University College London, London, UK
9
Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, and CGH Medical Center, Sterling, Illinois, USA
10
Department of Biostatistics, School of Public Health of Alabama, Birmingham, AL, USA
11
Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
12
Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
13
School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria, Australia
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Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK
15
NIHR University College London Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, UK
16
MEMO Research, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
17
Euroimmun Polska Sp. z o.o., Poland
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Municipal Hospital, Czestochowa, Poland
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Department of Gastroenterology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland
20
Polish Mothers Memorial Hospital Research Institute, Lodz Poland
21
Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland
22
Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland
Submission date: 2020-05-24
Acceptance date: 2020-05-24
Online publication date: 2020-06-04
 
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Cardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Poland. The LIPIDOGEN2015 sub-study was designed to include a random cohort of patients in order to analyse parameters related to lipid metabolism, oxidative stress, inflammatory responses, autoimmune disorders, and gene variants that confer susceptibility to cardiometabolic and atherosclerotic diseases.

Material and methods:
The recruitment was carried out by 438 primary care physicians in Poland. The expected number of patients recruited for the LIPIDOGRAM2015 study was 13,000–14,000 with 13–15% (1700–2000) also participating in the LIPIDOGEN2015 sub-study. Each patient had to complete a questionnaire concerning medical and family history, concomitant diseases, and pharmacotherapy. Anthropometric measurements were performed at the doctor’s office. For the LIPIDOGEN2015 sub-study, saliva samples for DNA isolation and blood samples for measurement of glycated haemoglobin, oxidative stress parameters, autoantibody levels, and inflammatory cytokine profile and apolipoprotein profile were collected. Follow-up data will be obtained from the National Health Fund in Poland.

Results:
The LIPIDOGRAM2015 and LIPIDOGEN2015 study cohort reflects the prevalence of cardiovascular risk factors and concomitant diseases, markers of oxidative stress, the presence of autoantibodies, inflammatory cytokine profile, and apolipoprotein profile, as well as genetic variants potentially conferring susceptibility to cardiometabolic and atherosclerotic diseases.

Conclusions:
This study presents the prevalence of different CV risk factors, with special emphasis on lipid disorders, and it assesses the relationship between inflammation, oxidative stress, and mutations in genes encoding proteins regulating lipid metabolism, as well as genes conferring susceptibility to cardiovascular, cardiometabolic, and related diseases.

eISSN:1896-9151
ISSN:1734-1922