Letter to the Editor
Amyloidosis of the head and neck: a clinicopathological study of cases with long term follow-up
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Submission date: 2012-02-12
Final revision date: 2012-06-16
Acceptance date: 2012-06-17
Online publication date: 2014-08-29
Publication date: 2014-08-31
Arch Med Sci 2014;10(4):846-852
Amyloidosis manifests idiopathic and extracellular deposits of fibrillar protein in tissues. It is probably caused by rearrangement in the immune system, though its pathogenesis is not still known thoroughly. The chronic inflammation with extensive tissue destroying, malignant proliferation of plasmacytes and autoimmune diseases promote expansion of amyloidosis. Various clinical types of that disease have an impact on its natural course, therapy and prognosis. Amyloidosis in the head and neck region is a rare condition although it is the commonest region for a localized form of amyloidosis. We investigated the cases of amyloidosis in the head and neck region surgically treated from 1996 to 2006 in Departments of Otolaryngology, Medical Universities of Lodz and Lublin. Our research revealed seven cases (six localized and one systemic), and the study was focused on the case history, results of laryngeal, general and pathological examination. Amyloidosis, although a rare disease it is not uncommon. Therefore, in each case of head and neck localized tumor, the need for a detailed and comprehensive patient evaluation cannot be overemphasized. Moreover, the role of a high index of amyloidosis suspicion in evaluating a patient with the head and neck tumor or swelling should be taken into consideration. Also, there is a need for a long close follow-up in all the patients after localized AL amyloidosis treatment due to recurrences. The current opinions on diagnosis, treatment and prognosis in patients with amyloidosis have been presented.
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