GASTROENTEROLOGY / RESEARCH LETTER
Plasma elafin, cathelicidin, and α-defensins are
increased in paediatric inflammatory Crohn’s disease
and reflect disease location
| 1 | Department of Paediatrics, Gastroenterology, and Nutrition, Jagiellonian University
Medical College, Krakow, Poland |
| 2 | Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow,
Poland |
CORRESPONDING AUTHOR
Andrzej Wędrychowicz
Jagiellonian University Medical College, Department of Pediatrics, Gastroenterology and Nutrition, Wielicka Str. 265, 30-663, Krakow, Poland
Jagiellonian University Medical College, Department of Pediatrics, Gastroenterology and Nutrition, Wielicka Str. 265, 30-663, Krakow, Poland
Submission date: 2021-04-10
Final revision date: 2021-05-31
Acceptance date: 2021-06-01
Publication date: 2021-06-11
Arch Med Sci 2021;17(4):1114–1117
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The aim of our study was to assess antimicrobial peptides in children with Crohn’s disease (CD).
Material and methods:
Plasma elafin, cathelicidin, alpha and beta-defensins were assessed in 35 children with CD using immunoassays. Phenotype and location of CD were assessed based on the results of endoscopic and radiology studies.
Results:
We found increased elafin, cathelicidin and alpha-defensins in children with inflammatory phenotype as compared to stricturising and penetrating phenotypes of CD. Additionally, we found increased elafin and cathelicidin in colonic location and alpha defensins in ileal CD locations.
Conclusions:
Assessing antimicrobial peptides may be helpful in estimating of phenotype and location of CD lesions.
The aim of our study was to assess antimicrobial peptides in children with Crohn’s disease (CD).
Material and methods:
Plasma elafin, cathelicidin, alpha and beta-defensins were assessed in 35 children with CD using immunoassays. Phenotype and location of CD were assessed based on the results of endoscopic and radiology studies.
Results:
We found increased elafin, cathelicidin and alpha-defensins in children with inflammatory phenotype as compared to stricturising and penetrating phenotypes of CD. Additionally, we found increased elafin and cathelicidin in colonic location and alpha defensins in ileal CD locations.
Conclusions:
Assessing antimicrobial peptides may be helpful in estimating of phenotype and location of CD lesions.
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