OBSTETRICS AND GYNAECOLOGY / SYSTEMATIC REVIEW/META-ANALYSIS
Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis
| 1 | Maternity Department, W.F. Maternity and Child Care Hospital, Weicheng District, China |
| 2 | Neonatology Department, Weifang Medical University, Weicheng District, China |
| 3 | Pharmacy Department, W.F. Maternity and Child Care Hospital, Weifang, Weicheng District, China |
| 4 | Public Computer Center, Weifang Medical University, Weifang, Kuiwen District, China |
Submission date: 2019-09-20
Final revision date: 2020-02-13
Acceptance date: 2020-02-23
Online publication date: 2020-04-15
Publication date: 2020-05-26
Arch Med Sci 2020;16(4):742–751
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D.
Material and methods:
PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed.
Results:
The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = –0.71, 95% CI: –0.91, –0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07–1.23). Vitamin D was negatively correlated with HOMA-IR (r = –0.62, 95% CI: –0.85, –0.39). The analysis showed no publication bias (Egger’s: p = 0.197; Begg’s: p = 0.786).
Conclusions:
Vitamin D is closely associated with the onset of GDM.
This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D.
Material and methods:
PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed.
Results:
The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = –0.71, 95% CI: –0.91, –0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07–1.23). Vitamin D was negatively correlated with HOMA-IR (r = –0.62, 95% CI: –0.85, –0.39). The analysis showed no publication bias (Egger’s: p = 0.197; Begg’s: p = 0.786).
Conclusions:
Vitamin D is closely associated with the onset of GDM.
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