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RESEARCH LETTER
Causal association of type 1 diabetes with pancreatic cancer: a multi-ancestry Mendelian randomization study
1
Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2
Shanghai Key Laboratory of Pancreatic Neoplasms Translational Research, Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3
State Key Laboratory of Systems Medicine for Cancer, Shanghai, China
4
Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China
5
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
These authors had equal contribution to this work
Submission date: 2025-12-02
Final revision date: 2026-03-26
Acceptance date: 2026-04-03
Online publication date: 2026-04-24
Corresponding author
Qionghua Xia
Qionghua Xia Department of General Surgery Pancreatic Disease Center Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai, China, 200025
Qionghua Xia Department of General Surgery Pancreatic Disease Center Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai, China, 200025
Shiyu Zhang
Department of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai, China, 200025
Department of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai, China, 200025
TOPICS
REFERENCES (21)
1.
Gregory GA, Robinson TIG, Linklater SE, International Diabetes Federation Diabetes Atlas Type 1 Diabetes in Adults Special Interest Group, et al. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. Lancet Diabetes Endocrinol 2022; 10: 741-60.
2.
Ebrahimpour Y, Khatami S, Saffar M, et al. A comprehensive review of novel advances in type 1 diabetes mellitus. J Diabetes 2025; 17: e70120.
3.
Suh S, Kim KW. Diabetes and cancer: cancer should be screened in routine diabetes assessment. Diabetes Metab J 2019; 43: 733-43.
4.
Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer: a meta-analysis. JAMA 1995; 273: 1605-9.
5.
Yuan F, Pfeiffer RM, Julián-Serrano S, et al. Autoimmune conditions and pancreatic cancer risk in older American adults. Int J Cancer 2023; 152: 172-82.
6.
Stevens RJ, Roddam AW, Beral V. Pancreatic cancer in type 1 and young-onset diabetes: systematic review and meta-analysis. Br J Cancer 2007; 96: 507-9.
7.
Carstensen B, Read SH, Friis S, et al. Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals. Diabetologia 2016; 59: 980-8.
8.
Hsu PC, Lin WH, Kuo TH, Lee HM, Kuo C, Li CY. A population-based cohort study of all-cause and site-specific cancer incidence among patients with type 1 diabetes mellitus in Taiwan. J Epidemiol 2015; 25: 567-73.
9.
Burgess S, Timpson NJ, Ebrahim S, Davey Smith G. Mendelian randomization: where are we now and where are we going? Int J Epidemiol 2015; 44: 379-88.
10.
Zhang T, Hua X, Mohindroo C, et al. Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis. J Natl Cancer Inst 2026; 118: 437-47.
11.
Wang C, Liu Z, Zhou Y, et al. Exploring the potential link between autoimmune diseases and pan-cancer: a multidatabase mendelian randomization analysis. J Immunol Res 2025; 2025: 6468979.
12.
Getu MA, Zhang X, Ying Y, Gong P. A two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers. Sci Rep 2025; 15: 11371.
13.
Zhao J, Li W, Chen L, Li M, Deng W. Casual effects of type 1 diabetes mellitus on site-specific digestive cancers: a Mendelian randomisation analysis. Front Endocrinol (Lausanne) 2024; 15: 1407329.
14.
Lu CN, Liu JB, Chen ZY, et al. The complex interplay between diabetes mellitus and pancreatic carcinogenesis: deciphering multifactorial mechanisms and identifying emerging therapeutic vulnerabilities. Cell Biosci 2025; 15: 135.
15.
Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, et al. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat Genet 2021; 53: 962-71.
16.
Rashkin SR, Graff RE, Kachuri L, et al. Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Nat Commun 2020; 11: 4423.
17.
Sakaue S, Kanai M, Tanigawa Y, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet 2021; 53: 1415-24.
18.
Lin Y, Nakatochi M, Hosono Y, et al. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun 2020; 11: 3175.
19.
Quattrin T, Mastrandrea LD, Walker LSK. Type 1 diabetes. Lancet 2023; 401: 2149-62.
20.
Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two-sample Mendelian randomization. Genet Epidemiol 2016; 40: 597-608.
21.
Hemani G, Zheng J, Elsworth B, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife 2018; 7: e34408.
| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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