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PANCREATOLOGY / CLINICAL RESEARCH
Increased blood urea nitrogen to serum albumin ratio is associated with poor prognosis in patients with acute pancreatitis: a retrospective cohort study
1
Department of International Medical Center, The First People’s Hospital of Foshan, Foshan, Guangdong, China
2
Department of Nursing, The First People’s Hospital of Foshan, Foshan, Guangdong, China
These authors had equal contribution to this work
Submission date: 2025-03-17
Final revision date: 2025-04-19
Acceptance date: 2025-04-25
Online publication date: 2025-05-22
Corresponding author
Xia Xiang
Department of Nursing The First People’s Hospital of Foshan No. 81 Lingnan North Road 528000 Foshan Guangdong, China
Department of Nursing The First People’s Hospital of Foshan No. 81 Lingnan North Road 528000 Foshan Guangdong, China
KEYWORDS
blood urea nitrogen to serum albumin ratioacute pancreatitisMIMIC-IV databasemortalityretrospective cohort study
TOPICS
ABSTRACT
Introduction:
The blood urea nitrogen to serum albumin ratio (BAR) may serve as a prognostic marker. This study evaluated its association with clinical outcomes in patients with acute pancreatitis (AP).
Material and methods:
We performed a retrospective cohort analysis using data from the MIMIC-IV 2.2 database, including 650 patients diagnosed with AP. The primary outcomes were 90-day and 365-day mortality. Cox proportional hazards models assessed the relationship between BAR and mortality. Restricted cubic spline (RCS) analysis examined the non-linear relationship.
Results:
Among the 650 patients, the mortality rates at 90 days and 365 days were 21.2% and 26.2%, respectively. Higher BAR levels correlated with increased 90-day and 365-day mortality (p < 0.001). BAR had hazard ratios (HR) of 1.04 (95% CI: 1.02–1.06) for 90-day and 1.04 (95% CI: 1.02–1.05) for 365-day mortality. ROC analysis revealed that BAR’s AUC was 0.738 for 90-day and 0.714 for 365-day mortality. Subgroup and sensitivity analyses indicated stable results across various conditions.
Conclusions:
Elevated BAR is significantly associated with increased mortality in AP patients, indicating its potential as a valuable prognostic marker in critical care settings.
The blood urea nitrogen to serum albumin ratio (BAR) may serve as a prognostic marker. This study evaluated its association with clinical outcomes in patients with acute pancreatitis (AP).
Material and methods:
We performed a retrospective cohort analysis using data from the MIMIC-IV 2.2 database, including 650 patients diagnosed with AP. The primary outcomes were 90-day and 365-day mortality. Cox proportional hazards models assessed the relationship between BAR and mortality. Restricted cubic spline (RCS) analysis examined the non-linear relationship.
Results:
Among the 650 patients, the mortality rates at 90 days and 365 days were 21.2% and 26.2%, respectively. Higher BAR levels correlated with increased 90-day and 365-day mortality (p < 0.001). BAR had hazard ratios (HR) of 1.04 (95% CI: 1.02–1.06) for 90-day and 1.04 (95% CI: 1.02–1.05) for 365-day mortality. ROC analysis revealed that BAR’s AUC was 0.738 for 90-day and 0.714 for 365-day mortality. Subgroup and sensitivity analyses indicated stable results across various conditions.
Conclusions:
Elevated BAR is significantly associated with increased mortality in AP patients, indicating its potential as a valuable prognostic marker in critical care settings.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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