GASTROENTEROLOGY / RESEARCH PAPER
Comparison of differences between initial and recurrent acute pancreatitis in the intensive care unit
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1
Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China
2
Division of Critical Care, Nanxiang Hospital of Jiading District, China
3
Department of Geriatrics, Medical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital/CNRS/Inserm/Côte d’Azur University, China
4
The State Key Laboratory of Medical Genomics, Pôle Sino-Français de Recherche en Sciences Du Vivant et Génomique, China
These authors had equal contribution to this work
Submission date: 2024-04-02
Final revision date: 2024-08-27
Acceptance date: 2024-08-28
Online publication date: 2024-09-06
Corresponding author
Wei Xu
Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Huangpu District, 200025, shanghai, China
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ABSTRACT
Introduction:
Previous studies have found that RAP may be at reduced risk for a clinically severe course and have reduced mortality. However, there is still a lack of data related to RAP admitted to ICU.
Material and methods:
Baseline characteristics of patients diagnosed with IAP and RAP from the MIMIC-IV database were extracted. In-hospital mortality and length of hospital/ICU stay were identified as outcomes. Binomial logistic regression analysis was performed to clarify the independent risk factors for in-hospital mortality in both groups, and we determined the best scoring system for prognosis prediction by plotting the ROC curves and DCA curves.
Results:
The in-hospital mortality rate was 13.96% in patients with IAP and 3.57% in patients with RAP. For IAP, the CCI, the BISAP score, and the SIRS score on the first day of admission were independent risk factors for in-hospital mortality. The SAPS II score almost always showed a higher net clinical benefit than the other scoring systems (BISAP, LODS, and OASIS). The BISAP score almost always showed a higher net clinical benefit than the others for RAP.
Conclusions:
RAP is less severe and has a lower risk of in-hospital mortality than IAP. The CCI, the BISAP score, and the SIRS score on the first day of admission were all independent risk factors for in-hospital mortality in patients with IAP. The SAPS II score was a better scoring system for predicting in-hospital mortality in patients with IAP. The BISAP score showed potential for predicting in-hospital mortality in patients with RAP.