NEUROLOGY / RESEARCH LETTER
Depressive symptoms in amnesic mild cognitive impairment: an FDG-PET/CT study
| 1 | U.O.C. Neurologia e Stroke Unit, ASST Settelaghi, Ospedale di Circolo, Varese, Italy |
| 2 | Department of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy |
| 3 | Nuclear Medicine Unit, ASST Settelaghi, Ospedale di Circolo, Varese, Italy |
| 4 | PhD program in Clinical and Experimental Medicine and Clinical Humanities, University of Insubria, Varese, Italy |
| 5 | Department of Medicine and Surgery, University of Insubria, Varese, Italy |
CORRESPONDING AUTHOR
Marco Mauri
U.O.C. Neurologia e Stroke Unit, ASST Settelaghi, Ospedale di Circolo, Varese, Italy Dept. of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy
U.O.C. Neurologia e Stroke Unit, ASST Settelaghi, Ospedale di Circolo, Varese, Italy Dept. of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy
Submission date: 2022-01-31
Final revision date: 2022-04-28
Acceptance date: 2022-05-04
Online publication date: 2022-06-06
Arch Med Sci 2022;18(4):1108–1111
KEYWORDS
mild cognitive impairmentdementiadepressionposition emission tomography/computed tomography with fluorodeoxy-glucose
TOPICS
ABSTRACT
Introduction:
The detection in mild cognitive impairment (MCI) of metabolic alterations suggestive of depression and/or of evolution to dementia.
Material and methods:
Sixty-nine MCI patients underwent clinical and imaging evaluation including position emission tomography/computed tomography with fluorodeoxy-glucose (FDG-PET/CT).
Results:
The metabolism mean values in parietal, temporal and pre-cuneus areas were lower in subjects who evolved to dementia, and in frontal and in anterior cingulate areas in depressed subjects. Abnormal metabolism values were higher in the frontal and parietal lobes, and in the precuneus in subjects who evolved to dementia independently from depression.
Conclusions:
In MCI FDG-PET/CT abnormality patterns suggest the presence of depression or the evolution to dementia.
The detection in mild cognitive impairment (MCI) of metabolic alterations suggestive of depression and/or of evolution to dementia.
Material and methods:
Sixty-nine MCI patients underwent clinical and imaging evaluation including position emission tomography/computed tomography with fluorodeoxy-glucose (FDG-PET/CT).
Results:
The metabolism mean values in parietal, temporal and pre-cuneus areas were lower in subjects who evolved to dementia, and in frontal and in anterior cingulate areas in depressed subjects. Abnormal metabolism values were higher in the frontal and parietal lobes, and in the precuneus in subjects who evolved to dementia independently from depression.
Conclusions:
In MCI FDG-PET/CT abnormality patterns suggest the presence of depression or the evolution to dementia.
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