RHEUMATOLOGY / RESEARCH PAPER
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The muscle quality index (MQI) is an increasingly prominent indicator of muscle status. The objective of this research is to analyze the connection between MQI and hyperuricemia.

Material and methods:
We performed a cross-sectional analysis utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2011 to 2014. Participants in this study were adults aged 20-59 years. Muscle quality index (MQI) was calculated as the ratio of handgrip strength (HGS) to appendicular skeletal muscle mass (ASM). Hyperuricemia was defined by serum uric acid concentrations exceeding 420 μmol/L (7 mg/dL) in males and 360 μmol/L (6 mg/dL) in females. Assessment of the MQI-hyperuricemia relationship involved logistic regression, analysis of subgroups, and the application of smooth curve fitting.

Results:
This research included 5,283 participants, of whom 716 had hyperuricemia. The prevalence of hyperuricemia decreased with higher quartiles of MQI (P<0.001). After correcting for confounders, MQI was closely associated with hyperuricemia (OR=0.59, 95%CI:0.46-0.77, P<0.001). Smooth curve fitting indicated a nonlinear association between the variables, with a threshold identified at 2.92. Subgroup analyses demonstrated that this association was particularly evident in participants with diabetes.

Conclusions:
Our findings revealed an inverse correlation between MQI and hyperuricemia, suggesting that preserving adequate muscle quality may be advantageous in reducing the risk of hyperuricemia. Further prospective research is needed.
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