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CARDIOLOGY / CLINICAL RESEARCH
The role of uric acid in mediating weight change patterns and cardiovascular health
1
Department of Child Healthcare, Wenzhou People’s Hospital, Zhejiang Province, China
2
Children’s Heart Center, Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Province, China
3
Zhejiang Provincial Clinical Research Center for Pediatric Disease, Zhejiang Province, China
4
Department of Gastroenterology, Pingyang Hospital of Wenzhou Medical University, Zhejiang Province, China
5
Department of Traditional Chinese Medicine, Wenzhou Yebo Proctology Hospital, Zhejiang Province, China
These authors had equal contribution to this work
Submission date: 2025-02-13
Final revision date: 2025-05-19
Acceptance date: 2025-05-25
Online publication date: 2025-06-23
Corresponding author
Maoping Chu
Institute of Cardiovascular Development and Translational Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Clinical Research Center for Pediatric Disease Zhejiang Province, China
Institute of Cardiovascular Development and Translational Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Clinical Research Center for Pediatric Disease Zhejiang Province, China
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Obesity and weight fluctuations across adulthood are well-documented risk factors for cardiovascular diseases (CVDs), while serum uric acid has emerged as a potential metabolic intermediary influencing cardiovascular health (CVH). However, limited research has explored the life-stage-specific relationships between weight changes, uric acid levels, and CVH trajectories, particularly the mediating role of uric acid in these associations.
Material and methods:
Multivariate linear regression was used to evaluate the associations between weight changes, uric acid levels, and CVH score patterns among 1,257 participants in NHANES cycles (2013–2018). Mediation analysis via bootstrap tests was conducted to investigate the role of uric acid in BMI‒CVH relationships across life stages, with stratified analysis by sex.
Results:
Obesity in early and middle adulthood was significantly associated with lower CVH scores in later adulthood. Weight changes exceeding 2.5 kg and stable obesity from middle to late adulthood were linked to increased cardiovascular risk. Serum uric acid levels were negatively associated with CVH scores and positively correlated with BMI and weight gain across all life stages. Uric acid mediated the relationship between BMI and CVH, with the mediating effect being most pronounced in early adulthood. Notably, this mediation effect showed gender differences, with a consistent effect across all stages in women but being significant only in late adulthood in men.
Conclusions:
These findings underscore the complex interplay between weight, uric acid, and cardiovascular health. Maintaining a stable weight and effectively managing uric acid levels, with consideration of sex-specific differences, are critical strategies for improving cardiovascular outcomes across the lifespan.
Obesity and weight fluctuations across adulthood are well-documented risk factors for cardiovascular diseases (CVDs), while serum uric acid has emerged as a potential metabolic intermediary influencing cardiovascular health (CVH). However, limited research has explored the life-stage-specific relationships between weight changes, uric acid levels, and CVH trajectories, particularly the mediating role of uric acid in these associations.
Material and methods:
Multivariate linear regression was used to evaluate the associations between weight changes, uric acid levels, and CVH score patterns among 1,257 participants in NHANES cycles (2013–2018). Mediation analysis via bootstrap tests was conducted to investigate the role of uric acid in BMI‒CVH relationships across life stages, with stratified analysis by sex.
Results:
Obesity in early and middle adulthood was significantly associated with lower CVH scores in later adulthood. Weight changes exceeding 2.5 kg and stable obesity from middle to late adulthood were linked to increased cardiovascular risk. Serum uric acid levels were negatively associated with CVH scores and positively correlated with BMI and weight gain across all life stages. Uric acid mediated the relationship between BMI and CVH, with the mediating effect being most pronounced in early adulthood. Notably, this mediation effect showed gender differences, with a consistent effect across all stages in women but being significant only in late adulthood in men.
Conclusions:
These findings underscore the complex interplay between weight, uric acid, and cardiovascular health. Maintaining a stable weight and effectively managing uric acid levels, with consideration of sex-specific differences, are critical strategies for improving cardiovascular outcomes across the lifespan.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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