Despite decades of research into lifestyle factors and medications, we still cannot effectively prevent the occurrence of ASCVD and its complications. Yet, only a small percentage of the healthcare budget is allocated to prevention, and only a few nations have introduced integrated programmes in primary prevention to promote health education, invest in health as early as possible, and prevent CVD events. The ILEP SiMple tIps for the heaLthy hEart (ILEP-SMILE) responds to this significant ineffectiveness by offering the most comprehensive population approach, including early, effective education, improvement of all recognised risk factors, alongside those that remain frequently unmeasured, such as lipoprotein(a), those often overlooked such as sleep disturbances and alcohol consumption, and the challenging aspect of stress, and its effect on cardiovascular health. Finally, ILEP-SMILE places considerable emphasis on adherence as a result of education; without it, even efficient lifestyle changes and innovative drugs may not yield the expected outcomes.