CARDIOLOGY / RESEARCH LETTER
The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
| 1 | Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu |
CORRESPONDING AUTHOR
Submission date: 2022-11-18
Final revision date: 2023-02-05
Acceptance date: 2023-02-05
Online publication date: 2023-02-24
Publication date: 2023-03-01
Arch Med Sci 2023;19(2):507–512
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF).
Material and methods:
The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes.
Results:
There is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group.
Conclusions:
Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.
The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF).
Material and methods:
The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes.
Results:
There is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group.
Conclusions:
Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.
RELATED ARTICLE
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.